Shanghai Institute of Cardiovascular Diseases

3 ARTICLES PUBLISHED IN JoVE

Medicine

Three-Dimensional Printing of a Complex Aortic Anomaly

Xiaoning Sun^1,2, Kai Zhu^1,2, Weijia Zhang^1,2,3,4, Hongqiang Zhang^1,2, Fazong Hu⁵, Chunsheng Wang^1,2

¹Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, ²Shanghai Institute of Cardiovascular Disease, ³State Key Laboratory of Molecular Engineering of Polymers, Fudan University, ⁴Institutes of Biomedical Sciences, Fudan University, ⁵Meditool Shanghai Enterprise Co., Ltd.

Here, we present a protocol to use three dimensional printed models for pre-operative planning and intra-operative reorganization of complicated vascular locations when handling a congenital aortic anomaly.

Bioengineering

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Nan Chen^1,2, Kai Zhu^1,2, Shiqiang Yan^3,4, Junmin Li^1,2, Tianyi Pan⁴, Mieradilijiang Abudupataer^1,2, Fazle Alam⁴, Xiaoning Sun^1,2, Li Wang^3,4, Chunsheng Wang^1,2

¹Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, ²Shanghai Institute of Cardiovascular Diseases, ³Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, ⁴Institutes of Biomedical Sciences and Department of Systems Biology for Medicine, Shanghai Medical College, Fudan University

Here, we developed a novel multilayered modified strategy for liquid-like bioinks (gelatin methacryloyl with low viscosity) to prevent the sedimentation of encapsulated cells.

Bioengineering

Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall

Mieradilijiang Abudupataer^*1, Xiujie Yin^*1, Bitao Xiang^*1, Nan Chen¹, Shiqiang Yan², Shichao Zhu¹, Yang Ming¹, Gang Liu¹, Xiaonan Zhou¹, Hao Lai¹, Chunsheng Wang¹, Kai Zhu¹, Jun Li¹

¹Department of Cardiac Surgery and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, ²Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University

Here, we developed a human aorta smooth muscle cell organ-on-a-chip model to replicate the in vivo biomechanical strain of smooth muscle cells in the human aortic wall.