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Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht

1 ARTICLES PUBLISHED IN JoVE

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Developmental Biology

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
Marek J. van Oostrom *1, Wilke H. M. Meijer *1, Katharina F. Sonnen 1
1Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht

A protocol for the culture and manipulation of mouse embryonic tissue on a microfluidic chip is provided. By applying pulses of pathway modulators, this system can be used to externally control signaling oscillations for the functional investigation of mouse somitogenesis.

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