An Orthotopic Mouse Model of Ovarian Cancer using Human Stroma to Promote MetastasisHuda I. Atiya 1, Taylor J. Orellana 2, Alyssa Wield 2, Leonard Frisbie 1, Lan G. Coffman 1,2
1Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, 2Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens’ Hospital, University of Pittsburgh Medical Center
Orthotopic engraftment of ovarian cancer cells mixed with human stromal cells provides a mouse model that exhibits rapid, diffuse metastatic behavior that is characteristic of human ovarian cancer. This model also allows for the study of tumor cell and stromal cell interactions, as well as their role in tumor progression and metastasis.
