University of Kragujevac

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

In Silico Clinical Trials for Cardiovascular Disease

Nenad Filipovic^1,2, Igor Saveljic^2,3, Tijana Sustersic^1,2, Miljan Milosevic^2,3, Bogdan Milicevic^1,2, Vladimir Simic^2,3, Milos Ivanovic^1,4, Milos Kojic^1,5

¹Bioengineering Research and Development Center BioIRC, ²Faculty of Engineering, University of Kragujevac, ³Institute for Information Technology, University of Kragujevac, ⁴Faculty of Science, University of Kragujevac, ⁵Serbian Academy of Science and Arts

This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic outcomes.