O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac HypertrophyNesrin Schmiedel 1, Anca Remes 1, Mohsen Valadan 2, Susanne Hille 1, Andrea Matzen 1, Derk Frank 1, Norbert Frey 2, Lorenz Lehmann 2, Oliver J. Müller 1
1Department of Internal Medicine III, German Centre for Cardiovascular Research, University Hospital Kiel, Partner Site Hamburg/Kiel/Lübeck, 2Internal Medicine III, German Centre for Cardiovascular Research, University Hospital Heidelberg, Partner Site Heidelberg/Mannheim
The present protocol describes a new technique of aortic banding in mice to induce pressure overload cardiac hypertrophy. For banding, a rubber ring with a fixed inner diameter is used. This new technique promises less variance and more reproducible data for future experiments.
