Intraspinal Cavity Injection of Human Mesenchymal Stem Cells and Tracking their Migration into the Rat BrainHyeongseop Kim 1,2, Seunghoon Lee 3, Jong Wook Chang 1,2, A ran Kim 4, Hyemin Jang 5,6,7, Duk L. Na 5,6,7
1Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, 2Stem Cell Institute, ENCell Co. Ltd, 3Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 4Animal Research and Molecular Imaging Center, Samsung Biomedical Research Institute, Samsung Medical Center, 5Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 6Neuroscience Center, Samsung Medical Center, 7Samsung Alzheimer Research Center, Samsung Medical Center
Several routes of administration can be used to deliver mesenchymal stem cells (MSCs) to the brain. In the present study, MSCs were delivered throughout the neuraxis and brain via intra-spinal cavity injection. MSCs were injected into the spinal cavities of rats, and stem cell migration was tracked and quantified.
