JoVE Logo

Sign In

Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy

1 ARTICLES PUBLISHED IN JoVE

image

Medicine

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Maria Luisa Belli 1, Emilio Mezzenga 1, Valentina Di Iorio 2, Monica Celli 3, Paola Caroli 3, Elisabeth Canali 3, Federica Matteucci 3, Elisa Tardelli 3, Ilaria Grassi 3, Maddalena Sansovini 3, Silvia Nicolini 3, Stefano Severi 3, Marta Cremonesi 4, Mahila Ferrari 5, Giovanni Paganelli 3, Anna Sarnelli 1
1Medical Physics Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 2Oncology Pharmacy, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 3Nuclear Medicine Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy, 4Radiation Research Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy, 5Medical Physics Unit, Istituto Europeo di Oncologia (IEO) IRCCS, Milano, Italy

This method estimates the absorbed dose of different structures for peptide-receptor-radionuclide-therapy (PRRT) with the possibility of avoiding organ overlap on 2D-projections. Serial whole-body planar images permit estimation of mean absorbed doses along the whole body, while the hybrid approach, combining planar images and 3D-SPECT/CT image, overcomes the limitations of structure overlapping.

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved