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Medtronic, Inc.

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Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Tinen L. Iles 1, Brian Howard 2, Stephen Howard 3, Stephen Quallich 2, Christopher Rolfes 2, Eric Richardson 4, Hanna R. Iaizzo 5, Paul A. Iaizzo 1
1Surgery, University of Minnesota, 2Biomedical Engineering, University of Minnesota, 3Medtronic, Inc., 4Bioengineering, Rice University, 5Pharmacy, University of Wisconsin

We have developed a swine model for the target delivery of pharmacological agents within the pericardial space/fluid. Using this approach, the relative benefits of administered agents on induced atrial fibrillation, relative refractory periods and/or ischemic protection can be investigated.

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