JoVE Logo

Sign In

Mestrelab Research

1 ARTICLES PUBLISHED IN JoVE

image

Chemistry

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Maria Victoria Silva Elipe 1, Lan Li 1, Karthik Nagapudi 2, Alan M. Kook 3, Carlos Cobas 4, Isaac Iglesias 4, Chen Peng 4
1Department of Attribute Sciences, Amgen, Inc., 2Small Molecule Pharmaceutical Sciences, Genentech, Inc., 3NMR Service + Consulting, 4Mestrelab Research

A simple and non-destructive technique that measures the average content of drug substances in formulated drug products containing fluorine using low-field fluorine-19 (19F) time-domain (TD) nuclear magnetic resonance (NMR) is presented here. The technique can be applied to the development and manufacturing of drugs in the pharmaceutical industry.

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved