Transcode Therapeutics Inc.

2 ARTICLES PUBLISHED IN JoVE

Cancer Research

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Alan Halim¹, Sujan Kumar Mondal^1,2, Nasreen Al-Qadi¹, Elizabeth Kenyon^1,2, Keith MacRenaris^3,5, Thomas V. O’Halloran^4,5, Zdravka Medarova⁶, Anna Moore^1,2

¹Precision Health Program, Michigan State University, ²Department of Radiology, College of Human Medicine, Michigan State University, ³Department of Microbiology, Genetics, & Immunology, College of Natural Science, Michigan State University, ⁴Department of Chemistry, College of Natural Science, Michigan State University, ⁵Elemental Health Institute, Michigan State University, ⁶Transcode Therapeutics Inc.

Here, we describe the protocol for in vivo delivery of magnetic iron oxide nanoparticles carrying RNA oligomers to metastatic breast cancer in animal models, providing a clinically viable approach for the therapeutic silencing of oncogenic nucleic acids.

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Bryan D. Kim^1,2, Sujan K. Mondal^1,3, Elizabeth Kenyon^1,3, Ming Chen^1,3, Christiane L. Mallett^3,4, Ana C. deCarvalho⁵, Zdravka Medarova⁶, Anna Moore^1,3

¹Precision Health Program, Michigan State University, ²Department of Biomedical Engineering, College of Engineering, Michigan State University, ³Department of Radiology, College of Human Medicine, Michigan State University, ⁴Institute for Quantitative Health Science and Engineering, Michigan State University, ⁵Henry Ford Health, ⁶Transcode Therapeutics Inc.

The blood-brain barrier is a significant hurdle in the delivery of therapies for glioblastoma, a disease for which there is no cure. Here, we report an in vivo image-guided iron oxide therapeutic nano platform that can bypass this physiological barrier by virtue of size and accumulate in the tumor.