Isolation of Splenic Microvesicles in a Murine Model of Intraperitoneal Bacterial InfectionHanine El Itawi 1, Fareeha Batool 1, Céline Stutz 1, Abdul Wahid Qureshi 1, Fatiha El Ghazouani 1,2, Olivier Huck 1,2, Florence Toti 1,2
1Universite de Strasbourg, 2Regenerative Nanomedicine, Centre de Recherche en Biomédecine de Strasbourg, INSERM (French National Institute of Health and Medical Research)
Microvesicles shed from the plasma membrane act as cellular effectors. Spleen microvesicles (SMVs) are surrogate markers of pathophysiological conditions. In rats and mice, SMV content and properties characterize aging or inflammation and are altered by cytoprotective treatments, making them a valuable yet abundant monitoring tool for preclinical research.
