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UNIVERSITY OF L'AQUILA

2 ARTICLES PUBLISHED IN JoVE

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Medicine

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
Lavinia Fiorani *1, Rita Maccarone *1, Nilisha Fernando 2,3, Linda Colecchi 1, Silvia Bisti 1,2, Krisztina Valter 2,3,4
1Biotechnology and Applied Clinical Sciences Department, University of L'Aquila, 2ARC Centre of Excellence in Vision Science, 3John Curtin School of Medical Research, Australian National University, 4ANU Medical School, Australian National University

This paper details how Elvax 40W can be used as a slow-release method for drug delivery to the adult rat retina. The protocol for preparing, loading, and delivering the drug-resin complex to the eye is described.

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Genetics

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Vincenzo De Iuliis 1, Sebastiano Ursi 1, Alfonso Pennelli 2, Marika Caruso 2, Sabrina Capodifoglio 2, Antonio Marino 1, Vincenzo Flati 3, Gianfranco Vitullo 1, Elena Toniato 2, Iole Robuffo 4, Stefano Martinotti 1,2
1SS Annunziata University Hospital, Unit of Clinical Molecular Biology and Predictive Medicine, University of Chieti, 2Department of Medical, Oral and Biotechnological Sciences, University of Chieti, 3Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 4CNR - Institute of Molecular Genetics, Section of Chieti

In the present study, we describe a methodology to analyze the C924T genotype. The protocol consists of three phases: DNA extraction, amplification by polymerase chain reaction (PCR), and analysis of the restriction fragment length polymorphism (RFLP) on agarose gel.

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