Millicent O. Sullivan
Department of Chemical and Biomolecular Engineering
University of Delaware
Millicent Sullivan is the Alvin B. and Julie O. Stiles Professor of Chemical & Biomolecular Engineering at the University of Delaware, and she also is a Professor in Biomedical Engineering at UD. Millie graduated from Princeton University with a B.S.E. degree in Chemical Engineering and a Certificate in Engineering Biology in 1998. Subsequently, she attended Carnegie Mellon University as a Clare Boothe Luce Graduate Fellow, where she earned her Ph.D. degree in Chemical Engineering with Professor Todd Przybycien in 2003. As a Ruth L. Kirchstein NIH postdoctoral fellow, Millie worked with Professor E. Helene Sage in the Matrix Biology/Hope Heart Program of the Benaroya Research Institute. In 2006, Millie moved to the University of Delaware. Her laboratory develops new biomaterials for drug delivery, gene delivery, and tissue engineering, with specific therapeutic targets including metastatic breast cancer, bone repair, wound healing, and cardiovascular repair. Additionally, her lab recently began working in synthetic cell design using engineered polypeptides. Specific fundamental foci include de novo peptide design, peptide and polymer self-assembly, and subcellular processing mechanisms. Sullivan is Core Director in the Delaware COBRE Center for Musculoskeletal Research, a member of the Penn Center for Targeted Therapeutics and Translational Nanomedicine (CT3N), and an Affiliate Member of the Delaware Biotechnology Institute. She is an AIMBE fellow, past Standing Member of the Gene and Drug Delivery (GDD) study section at NIH, and Honorary Professor of Chemical Engineering at the University of Melbourne, and she has been the recipient of awards and honors including a Fulbright Future Award, the Centennial Professorship, the NSF CAREER Award, and the Merck Faculty Fellow Award.
Formulation of a peptide nucleic acid based nucleic acid delivery construct.
Bioconjugate chemistry Mar, 2010 | Pubmed ID: 20131756
Structural and functional consequences of poly(ethylene glycol) inclusion on DNA condensation for gene delivery.
Microscopy research and technique Sep, 2010 | Pubmed ID: 20232467
Surface immobilization of plasmid DNA with a cell-responsive tether for substrate-mediated gene delivery.
Langmuir : the ACS journal of surfaces and colloids Mar, 2011 | Pubmed ID: 21323317
Histone H3 tail peptides and poly(ethylenimine) have synergistic effects for gene delivery.
Molecular pharmaceutics May, 2012 | Pubmed ID: 22280459
Polyplexes traffic through caveolae to the Golgi and endoplasmic reticulum en route to the nucleus.
Molecular pharmaceutics May, 2012 | Pubmed ID: 22420286
Using the epigenetic code to promote the unpackaging and transcriptional activation of DNA polyplexes for gene delivery.
Molecular pharmaceutics May, 2012 | Pubmed ID: 22489650
Requirements for the nuclear entry of polyplexes and nanoparticles during mitosis.
The journal of gene medicine Sep-Oct, 2012 | Pubmed ID: 22976512
Stimuli-responsive copolymer solution and surface assemblies for biomedical applications.
Chemical Society reviews Sep, 2013 | Pubmed ID: 23403471
Structural characterization of amphiphilic homopolymer micelles using light scattering, SANS, and cryo-TEM.
Macromolecules Aug, 2013 | Pubmed ID: 24058209
Structural changes in block copolymer micelles induced by cosolvent mixtures.
Soft matter Aug, 2011 | Pubmed ID: 24282441
Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway.
Nature communications Apr, 2014 | Pubmed ID: 24710204
Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.
Polymer chemistry Jun, 2014 | Pubmed ID: 25090637
Light-mediated activation of siRNA Release in diblock copolymer assemblies for controlled gene silencing.
Advanced healthcare materials Apr, 2015 | Pubmed ID: 25530259
Unlocking Chain Exchange in Highly Amphiphilic Block Polymer Micellar Systems: Influence of Agitation.
ACS macro letters Nov, 2014 | Pubmed ID: 25642383
Histone-targeted Polyplexes Avoid Endosomal Escape and Enter the Nucleus During Postmitotic Redistribution of ER Membranes.
Molecular therapy. Nucleic acids Feb, 2015 | Pubmed ID: 25668340
Fluorescent dye incorporation causes weakened gene association and intracellular aggregate formation in nonviral carriers.
The journal of gene medicine Mar-May, 2015 | Pubmed ID: 25731756
Importin-4 Regulates Gene Delivery by Enhancing Nuclear Retention and Chromatin Deposition by Polyplexes.
Molecular pharmaceutics Dec, 2015 | Pubmed ID: 26465823
Journey to the Center of the Cell: Current Nanocarrier Design Strategies Targeting Biopharmaceuticals to the Cytoplasm and Nucleus.
Current pharmaceutical design , 2016 | Pubmed ID: 26675220
Light-Mediated Activation of siRNA Release in Diblock Copolymer Assemblies for Controlled Gene Silencing.
Advanced healthcare materials Dec, 2015 | Pubmed ID: 26767924
Overexpression of caveolin-1 in inflammatory breast cancer cells enables IBC-specific gene delivery and prodrug conversion using histone-targeted polyplexes.
Biotechnology and bioengineering Dec, 2016 | Pubmed ID: 27241022
Integration of growth factor gene delivery with collagen-triggered wound repair cascades using collagen-mimetic peptides.
Bioengineering & translational medicine Jun, 2016 | Pubmed ID: 27981245
Efficient tuning of siRNA dose response by combining mixed polymer nanocarriers with simple kinetic modeling.
Acta biomaterialia Mar, 2017 | Pubmed ID: 28063990
Anionic Polymer and Quantum Dot Excipients to Facilitate siRNA Release and Self-Reporting of Disassembly in Stimuli-Responsive Nanocarrier Formulations.
Biomacromolecules Jun, 2017 | Pubmed ID: 28441861
ECM turnover-stimulated gene delivery through collagen-mimetic peptide-plasmid integration in collagen.
Acta biomaterialia 10, 2017 | Pubmed ID: 28865990
Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli-Triggered siRNA Release from Lipid-Polymer Nanocomplexes.
Advanced biosystems Aug, 2017 | Pubmed ID: 29392169
Histone-targeted gene transfer of bone morphogenetic protein-2 enhances mesenchymal stem cell chondrogenic differentiation.
Acta biomaterialia 04, 2018 | Pubmed ID: 29481871
Polymers at the Interface with Biology.
Biomacromolecules 08, 2018 | Pubmed ID: 30099879
Histone-Mimetic Gold Nanoparticles as Versatile Scaffolds for Gene Transfer and Chromatin Analysis.
Bioconjugate chemistry 11, 2018 | Pubmed ID: 30350573
Controlled Epidermal Growth Factor Receptor Ligand Display on Cancer Suicide Enzymes via Unnatural Amino Acid Engineering for Enhanced Intracellular Delivery in Breast Cancer Cells.
Bioconjugate chemistry 02, 2019 | Pubmed ID: 30615416
Gene delivery by peptide-assisted transport.
Current opinion in biomedical engineering Sep, 2018 | Pubmed ID: 30906908
Encapsulation of collagen mimetic peptide-tethered vancomycin liposomes in collagen-based scaffolds for infection control in wounds.
Acta biomaterialia 02, 2020 | Pubmed ID: 31843720
Hybrid hydrogels for biomedical applications.
Current opinion in chemical engineering Jun, 2019 | Pubmed ID: 31844607
Manipulation of the dually thermoresponsive behavior of peptide-based vesicles through modification of collagen-like peptide domains.
Bioengineering & translational medicine Jan, 2020 | Pubmed ID: 31989034
Targeted Drug Delivery via the Use of ECM-Mimetic Materials.
Frontiers in bioengineering and biotechnology , 2020 | Pubmed ID: 32133350
A CMP-based method for tunable, cell-mediated gene delivery from collagen scaffolds.
Journal of materials chemistry. B Dec, 2014 | Pubmed ID: 32262095
Enhanced wound healing via collagen-turnover-driven transfer of PDGF-BB gene in a murine wound model.
ACS applied bio materials Jun, 2020 | Pubmed ID: 32656505
Modular Hepatitis B Virus-like Particle Platform for Biosensing and Drug Delivery.
ACS nano 10, 2020 | Pubmed ID: 32924431
Site-Specific Bioconjugation Approaches for Enhanced Delivery of Protein Therapeutics and Protein Drug Carriers.
Bioconjugate chemistry 10, 2020 | Pubmed ID: 32931255
Mechanistic Design of Polymer Nanocarriers to Spatiotemporally Control Gene Silencing.
ACS biomaterials science & engineering Sep, 2016 | Pubmed ID: 33440593
Engineering bionanoparticles for improved biosensing and bioimaging.
Current opinion in biotechnology 10, 2021 | Pubmed ID: 34157601
Kinetic Modeling to Accelerate the Development of Nucleic Acid Formulations.
ACS nano 10, 2021 | Pubmed ID: 34636541
Therapeutic nanocarriers comprising extracellular matrix-inspired peptides and polysaccharides.
Expert opinion on drug delivery 11, 2021 | Pubmed ID: 34696691
Inhalable mRNA vaccines for respiratory diseases: a roadmap.
Current opinion in biotechnology Dec, 2021 | Pubmed ID: 34894574
Incorporation of Endosomolytic Peptides with Varying Disruption Mechanisms into EGFR-Targeted Protein Conjugates: The Effect on Intracellular Protein Delivery and EGFR Specificity in Breast Cancer Cells.
Molecular pharmaceutics Feb, 2022 | Pubmed ID: 35040326
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