In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor CellsWenchao Zhang 1,2, Xue Wei 1,2, Qingliang Wang 1,2, Kai Dai 1,2,3, Jing Wang 1,2,4, Changsheng Liu 2,3,4
1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 2Engineering Research Center for Biomedical Materials of the Ministry of Education, East China University of Science and Technology, 3Key Laboratory for Ultrafine Materials of the Ministry of Education, East China University of Science and Technology, 4Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology
Here, we established in vivo osteo-organoids triggered by bone morphogenetic protein-2-loaded gelatin scaffolds to harvest therapeutic hematopoietic stem/progenitor cells for the reconstruction of a damaged hematopoietic and immune system. Overall, this approach can provide a promising cell source for cell therapies.