Klinikum Chemnitz gGmbH

2 ARTICLES PUBLISHED IN JoVE

Medicine

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice

Chichi Xie^1,3, Weiwei Wei¹, Tao Zhang¹, Olaf Dirsch², Uta Dahmen¹

¹Department of General, Visceral and Vascular Surgery, Jena University Hospital, ²Institute of Pathology, Jena University Hospital, ³Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University

This film demonstrates how to acquire systemic and hepatic hemodynamics in mice. The whole monitoring includes acquisition of vital parameters, systemic blood pressure, central venous pressure, common hepatic artery flow rate, and portal vein pressure as well as the portal flow rate in mice.

Medicine

Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice

Chichi Xie¹, Weiwei Wei¹, Andrea Schenk³, Lars Ole Schwen³, Sara Zafarnia², Michael Schwier³, Felix Gremse², Isabel Jank¹, Olaf Dirsch⁴, Uta Dahmen¹

¹Department of General, Visceral and Vascular Surgery, Jena University Hospital, ²Experimental Molecular Imaging, RWTH Aachen University, ³Fraunhofer Institute for Medical Image Computing MEVIS, ⁴Institute of Pathology, Klinikum Chemnitz gGmbH

Tools used for visualizing vascular regeneration require methods for contrasting the vascular trees. This film demonstrated a delicate injection technique used to achieve optimal contrasting of the vascular trees and illustrate the potential benefits resulting from a detailed analysis of the resulting specimen using µCT and histological serial sections.