Results: Longitudinal Therapy Study of Mice Bearing Subcutaneous SW1222 Tumors
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Conclusion
Trascrizione
This protocol describes how to apply a pretargeted methodology to the targeted radiotherapy of cancer xenographs in the mouse model. Pretargeted radioimmunotherapy or PRIT allows us to inject the antibody and radioligand separately, and let the tw
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This protocol describes the synthesis and characterization of a trans-cyclooctene (TCO)-modified antibody and a 177Lu-labeled tetrazine (Tz) radioligand for pretargeted radioimmunotherapy (PRIT). In addition, it details the use of these two constructs for in vivo biodistribution and longitudinal therapy studies in a murine model of colorectal cancer.