Results: Representative Effects of CSF Modeling on Young Wild-Type Mouse Cognitive Abilities and Anxiety-Like Behaviors
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Conclusion
Trascrizione
Chronic sleep disturbance lead to neurodegenerative disease pathogenesis. We would like to provide a simple, stable, and long-term protocol to model frequent interruptions during human sleep to address this question. These mice minimizes handling
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Presented here is a protocol for chronic sleep fragmentation (CSF) model achieved by an electrically controlled orbital rotor, which could induce confirmed cognitive deficit and anxiety-like behavior in young wild-type mice. This model can be applied to explore the pathogenesis of chronic sleep disturbance and related disorders.