Results: Crohn's-Like Colitis Induced by Intra-Colonic TNBS Instillation
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Conclusion
Trascrizione
So in our protocol, intra-colonic instillation of TNBS leads to transmural inflammation at the instillation site and the mechanical distention in the segment proximal to inflammation. So this mimics stenotic Crohn's disease. As the proximal segmen
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The present protocol describes the development of a Crohn's-like colitis model in rodents. Transmural inflammation leads to stenosis at the TNBS instillation site, and mechanical enlargement is observed in the segment proximal to the stenosis. These changes allow studying mechanical stress in colitis.