A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery StenosisNadezda A. Stepicheva 1, Zhongfang Weng 1,2, Sarah Cao 3, Lesley M. Foley 4, Guodong Cao 1,2
1Department of Neurology, University of Pittsburgh, 2Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, 3School of Arts & Sciences, Washington University in St. Louis, 4Animal Imaging Center, University of Pittsburgh
The needle method of asymmetric bilateral common carotid artery stenosis is proposed to create a mouse model for vascular cognitive impairment and dementia. It results in longer-term outcomes compared to previously established models and is compatible with live MRI. Visual representation demonstrating the procedure provides guidance for mastering the surgery.
