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Ling-Xiao Deng

Spinal Cord and Brain Injury Research Group,
Stark Neurosciences Research Institute,
Department of Neurological Surgery and Goodman Campbell Brain and Spine,
Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman Campbell Brain and Spine

Indiana University-Indianapolis

BIOGRAPHY

I got my Ph.D degree in the department of Anatomy and Neuroscience in Indiana University School of Medicine and have performed research in cell transplantation and growth factor-mediated axonal regeneration and functional recovery following spinal cord injury. I has been well trained with strong technical expertise in spinal cord injury animal models, cell culture methods, cell transplantation, histology and immunohistochemistry, and behavior studies, using viral tool for neural tract tracing.Currently my research focuses on promoting the improvement of bladder function after spinal cord injury.

PUBLICATIONS

GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury.

Experimental neurology Jun, 2011 | Pubmed ID: 21316362

Co-transplantation of glial restricted precursor cells and Schwann cells promotes functional recovery after spinal cord injury.

Cell transplantation Jan, 2013 | Pubmed ID: 23295060

A novel growth-promoting pathway formed by GDNF-overexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2013 | Pubmed ID: 23536080

Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury.

Annals of neurology May, 2014 | Pubmed ID: 24623140

Grafted bone marrow stromal cells: a contributor to glial repair after spinal cord injury.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry Jun, 2015 | Pubmed ID: 24777423

Schwann cell transplantation and descending propriospinal regeneration after spinal cord injury.

Brain research Sep, 2015 | Pubmed ID: 25257034

Glucocorticoid Receptor β Acts as a Co-activator of T-Cell Factor 4 and Enhances Glioma Cell Proliferation.

Molecular neurobiology Dec, 2015 | Pubmed ID: 25301232

Unilateral microinjection of acrolein into thoracic spinal cord produces acute and chronic injury and functional deficits.

Neuroscience Jun, 2016 | Pubmed ID: 27058147

Sciatic nerve regeneration in KLF7-transfected acellular nerve allografts.

Neurological research Mar, 2016 | Pubmed ID: 27093235

Transcriptional and Epigenetic Regulation in Injury-Mediated Neuronal Dendritic Plasticity.

Neuroscience bulletin Feb, 2017 | Pubmed ID: 27730386

KLF7-transfected Schwann cell graft transplantation promotes sciatic nerve regeneration.

Neuroscience 01, 2017 | Pubmed ID: 27826105

AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury.

Neural plasticity , 2017 | Pubmed ID: 28884027

Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration.

Neuroscience bulletin Jun, 2018 | Pubmed ID: 29356943

Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery.

eLife 09, 2018 | Pubmed ID: 30207538

INSTITUTIONS

Indiana University-Indianapolis

JOVE ARTICLES

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Xiao-Jing Lin^1,2,3,

Shaonan Wen^2,6,

Ling-Xiao Deng³,

Heqiao Dai³,

Xiaolong Du³,

Chen Chen^3,4,

Melissa J. Walker^3,4,

Ting-Bao Zhao^1,5,

Xiao-Ming Xu³

¹Department of Spinal Cord Injury and Repair, Trauma and Orthopedics Institute of Chinese PLA, 960th Hospital, Joint Logistics Support Force of PLA,

²Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Academy of Military Sciences,

³Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman Campbell Brain and Spine, Indiana University School of Medicine,

⁴Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine,

⁵Department of Orthopedics, the Third Affiliated Hospital, Shandong University,

⁶Beijing Computing Center, Beijing Academy of Science and Technology

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