Department of Medicine
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Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography.
Circulation Apr, 2002 | Pubmed ID: 11956115
Detection of individual microbubbles of an ultrasound contrast agent: fundamental and pulse inversion imaging.
Academic radiology Aug, 2002 | Pubmed ID: 12188248
Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement.
Journal of the American College of Cardiology Aug, 2002 | Pubmed ID: 12204515
Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins.
Circulation Jan, 2003 | Pubmed ID: 12551871
Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3.
Circulation Jul, 2003 | Pubmed ID: 12835208
Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles.
Ultrasound in medicine & biology Dec, 2003 | Pubmed ID: 14698343
Detection of individual microbubbles of ultrasound contrast agents: imaging of free-floating and targeted bubbles.
Investigative radiology Mar, 2004 | Pubmed ID: 15076011
Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow.
Journal of controlled release : official journal of the Controlled Release Society May, 2004 | Pubmed ID: 15120903
Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo.
Diabetes Jun, 2004 | Pubmed ID: 15161743
Molecular imaging with targeted ultrasound contrast microbubbles.
Ernst Schering Research Foundation workshop , 2005 | Pubmed ID: 15524217
Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging.
Bioconjugate chemistry Jan-Feb, 2005 | Pubmed ID: 15656569
Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control Mar, 2005 | Pubmed ID: 15857050
Simultaneous integrin alphavbeta3 and glycoprotein IIb/IIIa inhibition causes reduction in infarct size in a model of acute coronary thrombosis and primary angioplasty.
Cardiovascular research Jun, 2005 | Pubmed ID: 15914120
Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression.
Circulation Jun, 2005 | Pubmed ID: 15956135
Ultrasound-microbubble-induced neovascularization in mouse skeletal muscle.
Ultrasound in medicine & biology Oct, 2005 | Pubmed ID: 16223645
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease.
Gastroenterology Jan, 2006 | Pubmed ID: 16401463
Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications.
Investigative radiology Mar, 2006 | Pubmed ID: 16481920
3D perfusion mapping in post-infarct mice using myocardial contrast echocardiography.
Ultrasound in medicine & biology Jun, 2006 | Pubmed ID: 16785003
Deformable gas-filled microbubbles targeted to P-selectin.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2006 | Pubmed ID: 16887229
Microparticle adhesive dynamics and rolling mediated by selectin-specific antibodies under flow.
Biotechnology and bioengineering Feb, 2007 | Pubmed ID: 16917925
Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging.
Investigative radiology Oct, 2006 | Pubmed ID: 16971795
Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow.
Contrast media & molecular imaging Nov-Dec, 2006 | Pubmed ID: 17191766
Enhanced targeting of ultrasound contrast agents using acoustic radiation force.
Ultrasound in medicine & biology Jul, 2007 | Pubmed ID: 17445966
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module.
Nature Nov, 2007 | Pubmed ID: 17960134
Ultrasound molecular imaging with targeted microbubble contrast agents.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Nov-Dec, 2007 | Pubmed ID: 18022115
Ultrasonic microbubble destruction stimulates therapeutic arteriogenesis via the CD18-dependent recruitment of bone marrow-derived cells.
Arteriosclerosis, thrombosis, and vascular biology Jun, 2008 | Pubmed ID: 18403725
Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue.
Investigative radiology May, 2008 | Pubmed ID: 18424953
Microbubbles in ultrasound-triggered drug and gene delivery.
Advanced drug delivery reviews Jun, 2008 | Pubmed ID: 18486268
Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis.
Small (Weinheim an der Bergstrasse, Germany) Oct, 2008 | Pubmed ID: 18720443
Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging.
Medical & biological engineering & computing Aug, 2009 | Pubmed ID: 19517153
Action at a distance: lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticles.
Langmuir : the ACS journal of surfaces and colloids Sep, 2009 | Pubmed ID: 19621909
Muscle contraction, but not insulin, increases microvascular blood volume in the presence of free fatty acid-induced insulin resistance.
Diabetes Nov, 2009 | Pubmed ID: 19675134
Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels.
Ultrasound in medicine & biology Dec, 2009 | Pubmed ID: 19828229
Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles.
Journal of vascular research , 2010 | Pubmed ID: 19923850
Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonance.
Circulation. Cardiovascular imaging Jul, 2010 | Pubmed ID: 20442371
Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery.
Journal of controlled release : official journal of the Controlled Release Society Nov, 2010 | Pubmed ID: 20691227
Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery.
Ultrasound in medicine & biology Sep, 2010 | Pubmed ID: 20800174
Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles.
Ultrasound in medicine & biology Nov, 2010 | Pubmed ID: 20800945
An ultrasound contrast agent targeted to P-selectin detects activated platelets at supra-arterial shear flow conditions.
Investigative radiology Oct, 2010 | Pubmed ID: 20808239
Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating.
Journal of neurosurgery Jun, 2011 | Pubmed ID: 21214331
Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results.
Molecular imaging Aug, 2011 | Pubmed ID: 21521555
Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation.
Journal of controlled release : official journal of the Controlled Release Society Aug, 2011 | Pubmed ID: 21549778
Phagocytic activity of neuronal progenitors regulates adult neurogenesis.
Nature cell biology Jul, 2011 | Pubmed ID: 21804544
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2011 | Pubmed ID: 21900578
Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report.
Arteriosclerosis, thrombosis, and vascular biology Dec, 2011 | Pubmed ID: 21960561
Inhibitor of differentiation-3 mediates high fat diet-induced visceral fat expansion.
Arteriosclerosis, thrombosis, and vascular biology Feb, 2012 | Pubmed ID: 22075252
Nanobody-coupled microbubbles as novel molecular tracer.
Journal of controlled release : official journal of the Controlled Release Society Mar, 2012 | Pubmed ID: 22197777
Monocyte and/or macrophage infiltration of heart after myocardial infarction: MR imaging by using T1-shortening liposomes.
Radiology Aug, 2012 | Pubmed ID: 22723500
Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2012 | Pubmed ID: 22800583
Microbubbles as ultrasound contrast agents for molecular imaging: preparation and application.
AJR. American journal of roentgenology Aug, 2012 | Pubmed ID: 22826389
Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2013 | Pubmed ID: 23142578
Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control Oct, 2012 | Pubmed ID: 23143566
Ultrasound-mediated vascular gene transfection by cavitation of endothelial-targeted cationic microbubbles.
JACC. Cardiovascular imaging Dec, 2012 | Pubmed ID: 23236976
Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.
Nature May, 2013 | Pubmed ID: 23615608
Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway.
Journal of the American Society of Nephrology : JASN Sep, 2013 | Pubmed ID: 23907510
Ultrasound contrast materials in cardiovascular medicine: from perfusion assessment to molecular imaging.
Journal of cardiovascular translational research Oct, 2013 | Pubmed ID: 23913363
MR-guided focused ultrasound surgery, present and future.
Medical physics Aug, 2013 | Pubmed ID: 23927296
Shear forces from flow are responsible for a distinct statistical signature of adherent microbubbles in large vessels.
Molecular imaging Sep, 2013 | Pubmed ID: 23981785
Synthesis and characterization of transiently stable albumin-coated microbubbles via a flow-focusing microfluidic device.
Ultrasound in medicine & biology Feb, 2014 | Pubmed ID: 24342914
Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force.
Physics in medicine and biology Jan, 2014 | Pubmed ID: 24374866
Nucleic acid delivery with microbubbles and ultrasound.
Advanced drug delivery reviews Jun, 2014 | Pubmed ID: 24486388
Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology Sep, 2014 | Pubmed ID: 24903900
Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.
Journal of controlled release : official journal of the Controlled Release Society Sep, 2014 | Pubmed ID: 24979210
Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.
Ultrasound in medicine & biology Oct, 2014 | Pubmed ID: 25130449
Ultrasound-based measurement of molecular marker concentration in large blood vessels: a feasibility study.
Ultrasound in medicine & biology Jan, 2015 | Pubmed ID: 25308943
The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome.
PloS one , 2014 | Pubmed ID: 25343339
In vivo imaging of microfluidic-produced microbubbles.
Biomedical microdevices Feb, 2015 | Pubmed ID: 25663444
Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles.
Small (Weinheim an der Bergstrasse, Germany) Jul, 2015 | Pubmed ID: 25703465
Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles.
Annals of biomedical engineering Nov, 2015 | Pubmed ID: 25893508
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.
Immunity Apr, 2015 | Pubmed ID: 25902482
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic.
Oncotarget May, 2015 | Pubmed ID: 25926554
Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26122651
Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.
Investigative radiology Nov, 2015 | Pubmed ID: 26135018
Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy.
Investigative radiology Sep, 2015 | Pubmed ID: 26200224
Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles.
Advances in experimental medicine and biology , 2016 | Pubmed ID: 26486340
Regulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number.
Biorheology , 2015 | Pubmed ID: 26600268
Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging.
Bioconjugate chemistry Feb, 2016 | Pubmed ID: 26603129
Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2016 | Pubmed ID: 26732553
Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2016 | Pubmed ID: 26961944
Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.
Journal of neuroinflammation 06, 2016 | Pubmed ID: 27260166
Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin.
Ultrasound in medicine & biology 09, 2016 | Pubmed ID: 27260243
The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging.
Investigative radiology 02, 2017 | Pubmed ID: 27495188
Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See?
Investigative radiology 12, 2016 | Pubmed ID: 27654582
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation.
Nature 11, 2016 | Pubmed ID: 27820945
Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.
Journal of the American Society of Nephrology : JASN Jun, 2017 | Pubmed ID: 28062568
Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta.
Investigative radiology 09, 2017 | Pubmed ID: 28430714
Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.
Nano letters 06, 2017 | Pubmed ID: 28511006
Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification.
PloS one , 2017 | Pubmed ID: 28686673
Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.
Nanomedicine : nanotechnology, biology, and medicine Nov, 2017 | Pubmed ID: 28754465
Size Exclusion HPLC Detection of Small-Size Impurities as a Complementary Means for Quality Analysis of Extracellular Vesicles.
Journal of circulating biomarkers Jan-Dec, 2015 | Pubmed ID: 28936242
Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice.
Free radical biology & medicine 12, 2017 | Pubmed ID: 28982599
In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device.
Annals of biomedical engineering Feb, 2018 | Pubmed ID: 29192346
Targeting of microbubbles: contrast agents for ultrasound molecular imaging.
Journal of drug targeting Jun - Jul, 2018 | Pubmed ID: 29258335
Klf4 has an unexpected protective role in perivascular cells within the microvasculature.
American journal of physiology. Heart and circulatory physiology 08, 2018 | Pubmed ID: 29631369
Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.
Theranostics , 2018 | Pubmed ID: 29774075
A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles.
Lab on a chip 08, 2018 | Pubmed ID: 30070301
Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction.
Clinical science (London, England : 1979) 12, 2018 | Pubmed ID: 30442812
Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations.
Langmuir : the ACS journal of surfaces and colloids 08, 2019 | Pubmed ID: 30509068
Efficacy of Sonothrombolysis Using Microbubbles Produced by a Catheter-Based Microfluidic Device in a Rat Model of Ischemic Stroke.
Annals of biomedical engineering Apr, 2019 | Pubmed ID: 30689066
Ultrasound molecular imaging for differentiation of benign and malignant tumors in patients.
Quantitative imaging in medicine and surgery Dec, 2018 | Pubmed ID: 30701161
Moving toward Noninvasive, Focused Ultrasound Therapeutic Delivery of Drugs in the Brain: Prolonged Opening of Blood-Brain Barrier May Not Be Needed.
Radiology May, 2019 | Pubmed ID: 30917292
Correction: A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles.
Lab on a chip 05, 2019 | Pubmed ID: 31026008
Validation of Normalized Singular Spectrum Area as a Classifier for Molecularly Targeted Microbubble Adherence.
Ultrasound in medicine & biology 09, 2019 | Pubmed ID: 31227262
Monitoring Oxygenation Levels Deep in the Tumor Core: Noninvasive Imaging of Hypoxia, Now in Real-Time 3D.
Cancer research Sep, 2019 | Pubmed ID: 31519775
Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects.
PloS one , 2019 | Pubmed ID: 31725756
Pulsed ultrasound attenuates the hyperglycemic exacerbation of myocardial ischemia-reperfusion injury.
The Journal of thoracic and cardiovascular surgery Nov, 2019 | Pubmed ID: 31839230
liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects.
Theranostics , 2020 | Pubmed ID: 31903139
Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption.
Proceedings of the National Academy of Sciences of the United States of America 03, 2020 | Pubmed ID: 32123081
Closed-loop feedback control of microbubble diameter from a flow-focusing microfluidic device.
Biomicrofluidics May, 2020 | Pubmed ID: 32454925
Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection.
Science advances May, 2020 | Pubmed ID: 32494662
Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles.
Investigative radiology Jun, 2020 | Pubmed ID: 32569011
Ultrasound Molecular Imaging of Cancer: Design and Formulation Strategies of Targeted Contrast Agents.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer , 2020 | Pubmed ID: 32594391
From Anatomy to Functional and Molecular Biomarker Imaging and Therapy: Ultrasound Is Safe, Ultrafast, Portable, and Inexpensive.
Investigative radiology Sep, 2020 | Pubmed ID: 32776766
Wilson Wang*,1,
Yanrong Zhang*,2,
Matthew J. Anzivino1,
Edward H. Bertram3,
James Woznak1,4,
Alexander Klibanov5,
Erik Dumont6,
Max Wintermark*,2,
Kevin S. Lee*,1,7,8
1Department of Neuroscience, University of Virginia,
2Department of Radiology, Stanford University,
3Department of Neurology, University of Virginia,
4Global Internship Program, Focused Ultrasound Foundation,
5Department of Medicine, University of Virginia,
6, Image Guided Therapy,
7Department of Neurosurgery, University of Virginia,
8Center for Brain, Immunology, and Glia, University of Virginia
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