Department of Biomedical Engineering,
Cardiovascular Biophysics Lab
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Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2002 | Pubmed ID: 11867747
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology Apr, 2002 | Pubmed ID: 12007532
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice.
Molecular and cellular biology Jul, 2002 | Pubmed ID: 12077332
The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
European journal of pharmacology Aug, 2002 | Pubmed ID: 12176114
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.
Molecular endocrinology (Baltimore, Md.) Jan, 2003 | Pubmed ID: 12511609
Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor.
Alcoholism, clinical and experimental research Jun, 2005 | Pubmed ID: 15976520
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters Aug, 2005 | Pubmed ID: 15982875
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
The Journal of experimental medicine Aug, 2005 | Pubmed ID: 16103409
Diet induction of monocyte chemoattractant protein-1 and its impact on obesity.
Obesity research Aug, 2005 | Pubmed ID: 16129712
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16326714
Sherrington innervational surgery in the treatment of chronic sixth nerve paresis.
Binocular vision & strabismus quarterly , 2005 | Pubmed ID: 16359278
Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2006 | Pubmed ID: 16954192
Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity.
Cell metabolism Feb, 2010 | Pubmed ID: 20096642
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.
Bioorganic & medicinal chemistry letters Mar, 2010 | Pubmed ID: 20167483
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorganic & medicinal chemistry letters Apr, 2010 | Pubmed ID: 20207541
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Bioorganic & medicinal chemistry letters Aug, 2010 | Pubmed ID: 20598533
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters Aug, 2010 | Pubmed ID: 20598882
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorganic & medicinal chemistry letters Aug, 2010 | Pubmed ID: 20621473
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorganic & medicinal chemistry letters Nov, 2010 | Pubmed ID: 20933410
Imaging of apoptosis in the heart with nanoparticle technology.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Jan-Feb, 2011 | Pubmed ID: 20945336
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Bioorganic & medicinal chemistry letters Apr, 2011 | Pubmed ID: 21439820
Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5.
Nanomedicine : nanotechnology, biology, and medicine Apr, 2012 | Pubmed ID: 21704591
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21775438
Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium.
Circulation. Cardiovascular imaging Nov, 2011 | Pubmed ID: 21836081
Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene.
Environmental and molecular mutagenesis Apr, 2012 | Pubmed ID: 22351378
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival.
Theranostics , 2012 | Pubmed ID: 22400062
In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium.
Journal of biomedical optics May, 2012 | Pubmed ID: 22612124
Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.
Angewandte Chemie (International ed. in English) Jul, 2012 | Pubmed ID: 22684680
Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Oct, 2012 | Pubmed ID: 23061749
Thrombotic thrombocytopenic purpura in pediatric patients.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics Nov, 2012 | Pubmed ID: 23146723
Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo.
PloS one , 2012 | Pubmed ID: 23226295
Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems.
ACS nano Mar, 2013 | Pubmed ID: 23373524
Characterization of printable cellular micro-fluidic channels for tissue engineering.
Biofabrication Jun, 2013 | Pubmed ID: 23458889
Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo.
Circulation. Cardiovascular imaging May, 2013 | Pubmed ID: 23537953
Molecular magnetic resonance imaging of pulmonary fibrosis in mice.
American journal of respiratory cell and molecular biology Dec, 2013 | Pubmed ID: 23927643
Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria.
Chemical communications (Cambridge, England) Nov, 2013 | Pubmed ID: 24072060
Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury.
Journal of the American Heart Association , 2014 | Pubmed ID: 24390148
Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo.
Circulation Apr, 2014 | Pubmed ID: 24619466
Direct coupling of annexin A5 to VSOP yields small, protein-covered nanoprobes for MR imaging of apoptosis.
Contrast media & molecular imaging Jul-Aug, 2014 | Pubmed ID: 24706613
Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.
Science translational medicine Dec, 2014 | Pubmed ID: 25504881
Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug.
Nanoscale Jan, 2015 | Pubmed ID: 25572921
A comparison of instrumentation methods to estimate thoracolumbar motion in field-based occupational studies.
Applied ergonomics May, 2015 | Pubmed ID: 25683549
Sina Mossahebi2,5,
Simeng Zhu2,5,
Howard Chen1,5,
Leonid Shmuylovich3,5,
Erina Ghosh1,5,
Sándor J. Kovács4,5
1Department of Biomedical Engineering, Washington University in St. Louis,
2Department of Physics, Washington University in St. Louis,
3Division of Biology and Biomedical Sciences, Washington University in St. Louis,
4Department of Medicine, Cardiovascular Division, Washington University in St. Louis,
5Cardiovascular Biophysics Lab, Washington University in St. Louis
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