Mitchell Chesler

Surface carbonic anhydrase activity on astrocytes and neurons facilitates lactate transport.

Regulation and modulation of pH in the brain.

Role of Na+-H+ and Na+-Ca2+ exchange in hypoxia-related acute astrocyte death.

Failure and function of intracellular pH regulation in acute hypoxic-ischemic injury of astrocytes.

Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain.

Functional demonstration of surface carbonic anhydrase IV activity on rat astrocytes.

Kinetics of activity-evoked pH transients and extracellular pH buffering in rat hippocampal slices.

Fabrication and use of high-speed, concentric h+- and Ca2+-selective microelectrodes suitable for in vitro extracellular recording.

Regulation of postsynaptic Ca2+ influx in hippocampal CA1 pyramidal neurons via extracellular carbonic anhydrase.

Endogenous alkaline transients boost postsynaptic NMDA receptor responses in hippocampal CA1 pyramidal neurons.

Carbonic anhydrases CA4 and CA14 both enhance AE3-mediated Cl--HCO3- exchange in hippocampal neurons.

Rapid rise of extracellular pH evoked by neural activity is generated by the plasma membrane calcium ATPase.

Barium plateau potentials of CA1 pyramidal neurons elicit all-or-none extracellular alkaline shifts via the plasma membrane calcium ATPase.

Preemptive regulation of intracellular pH in hippocampal neurons by a dual mechanism of depolarization-induced alkalinization.

NMDA receptor-dependent afterdepolarizations are curtailed by carbonic anhydrase 14: regulation of a short-term postsynaptic potentiation.

Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.

Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift.