Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's DiseaseTheresa M. Harrison 1, Donald G. McLaren 2, Teena D. Moody 1, Jamie D. Feusner 1, Susan Y. Bookheimer 1
1Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 2Biospective, Inc.
This manuscript describes how to implement a psychophysiological interaction analysis to reveal task-dependent changes in functional connectivity between a selected seed region and voxels in other regions of the brain. Psychophysiological interaction analysis is a popular method to examine task effects on brain connectivity, distinct from traditional univariate activation effects.
