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United States Army Medical Research Institute of Infectious Diseases

2 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy
Jennifer Chua 1, Nathan A. Fisher 2, Shane D. Falcinelli 1, David DeShazer 1, Arthur M. Friedlander 3
1Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 2Southern Research, 3Headquarters Division, United States Army Medical Research Institute of Infectious Diseases

We present a protocol to utilize the Madagascar hissing cockroach as an alternative non-mammalian animal model to conduct bacterial virulence, pathogenesis, drug toxicity, drug efficacy, and innate immune response studies.

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Immunology and Infection

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Jennifer Chua *1, Donald J. Chabot *1, Tammy Putmon-Taylor 1,3, Arthur M. Friedlander 2
1Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 2Headquarters Division, United States Army Medical Research Institute of Infectious Diseases, 3Bioqual

The opsono-adherence assay is an alternative method to the opsono-phagocytic killing assay to evaluate the opsonic functions of antibodies in vaccine development.

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