A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural ProductsChristopher E. Malmberg 1, Stephen Chamberland 2
1Department of Chemistry, Central Washington University, 2Department of Chemistry, Utah Valley University
Here, we present a protocol for direct, early stage guanidinylation that enables rapid total synthesis of aminoguanidine-containing small organic molecules. An advanced synthetic intermediate used in the synthesis of a blood coagulation factor XIa inhibitor was prepared using this protocol.
