0:00
Overview
1:09
Considerations for the Specialized Injections
4:46
Intradermal Administration
6:30
Intranasal Administration
7:59
Intracranial Administration in Neonatal Rodents
10:38
Applications
11:56
Summary
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN
There are many commonly used routes for compound administration in laboratory mice and rats. However, certain protocols may require the use of less commonly used routes, including intradermal, intranasal, and intracranial injections. Specialized training is essential for these procedures to be performed successfully. Justification for these routes may need to be provided to gain Institutional Animal Care and Use Committee (IACUC) approval.
1. Intradermal administration
The administration of compounds into animals can have a significant effect on both the wellbeing of the animal and the outcome of the experimental data and scientific value. The proper method of delivery is essential to the success of the experiment. Many factors must be considered to determine the best route, including the scientific aim of the study, the pH of the substance, the required dosage volume, the viscosity of the substance, and the wellbeing of the animals. Technical expertise is also a requirement for all in
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