Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

0:38

Manual Solid-Phase Peptide Synthesis

2:42

Formation of Thioether Linker by On-Resin Cyclization

5:29

Thioether Linker Formation via Intermolecular Thio-ene Reaction and Peptide Cyclization via Macrolactamization

7:02

Solution-Phase Formation of a Vinyl Sulfide Linker

8:41

Results: Thioether- and Vinyl Sulfide-Tethered Cyclic Peptides

10:42

Conclusion