Patient-derived Heterogeneous Xenograft Model of Pancreatic Cancer Using Zebrafish Larvae as Hosts for Comparative Drug Assessment
April 30th, 2019
•This protocol describes optimization procedures in a virus-based dual fluorescence-labeled tumor xenograft model using larval zebrafish as hosts. This heterogeneous xenograft model mimics the tissue composition of pancreatic cancer microenvironment in vivo and serves as a more precise tool for assessing drug responses in personalized zPDX (zebrafish patient-derived xenograft) models.
Related Videos
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
A Melanoma Patient-Derived Xenograft Model
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease
Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
The Establishment and Utilization of Patient Derived Xenograft Models of Central Nervous System Metastasis
Zebrafish Larvae as a Model to Evaluate Potential Radiosensitizers or Protectors
Copyright © 2024 MyJoVE Corporation. 판권 소유