Name: management of the uncinate process in no-touch laparoscopic pancreaticoduodenectomy
Uploaded: 2023-05-05T12:20:00
Description: Watch this Scientific Journal Video about Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy at JoVE.com

Our article #64904 was supported by the Research project of Traditional Chinese Medicine Bureau of Guangdong Province (ID:20222077).

This study was approved by the Ethics Committee of the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, and informed written consent was obtained from the patients involved in this study.
1. Preoperative work-up
<ol>
	<li>Perform the high-resolution contrast-enhanced CT12,13 (see Table of Materials) to assess the tumor&#39;s extent and search for any abnormal vasculature.</li>
...

<ol>
	<li>L&#233;ger, L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pancreatic+Surgery.">Pancreatic Surgery.</a> Chugai-Igakusha. , (1984).</li><li>O'Sullivan, A. 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J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Dual-source+dual-energy+multidetector+CT+for+the+evaluation+of+pancreatic+tumours.">Dual-source dual-energy multidetector CT for the evaluation of pancreatic tumours.</a> The British Journal of Radiology. 85 (1018), 891-898 (2012).</li><li>Mao, G. -. Q., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+application+value+of+spectral+imaging+in+diagnosis+of+pancreatic+adenocarcinoma+by+dual+source+CT.">The application value of spectral imaging in diagnosis of pancreatic adenocarcinoma by dual source CT.</a> Journal of Medical Imaging. 26 (07), 1243-1246 (2016).</li><li>Higgs, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Guidelines+for+the+management+of+tracheal+intubation+in+critically+ill+adults.">Guidelines for the management of tracheal intubation in critically ill adults.</a> British Journal of Anaesthesia. 120 (2), 323-352 (2018).</li><li>Schultz, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparison+of+Narcotrend+Index,+Bispectral+Index,+spectral+and+entropy+parameters+during+induction+of+propofol-remifentanil+anaesthesia.">Comparison of Narcotrend Index, Bispectral Index, spectral and entropy parameters during induction of propofol-remifentanil anaesthesia.</a> Journal of Clinical Monitoring and Computing. 22 (2), 103-111 (2008).</li><li>Cole, W. 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Idea to prevent serious complications.</a> Journal of the Pancreas. 13 (1), 1-6 (2012).</li><li>Li, M. Q. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+practice+guidelines+for+the+interventional+treatment+of+advanced+pancreatic+carcinoma+(on+trial)+(6th+edition).">Clinical practice guidelines for the interventional treatment of advanced pancreatic carcinoma (on trial) (6th edition).</a> Journal of Clinical Hepatology. 38 (06), 1242-1251 (2022).</li><li>Sugiyama, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Vascular+anatomy+of+mesopancreas+in+pancreatoduodenectomy+using+an+intestinal+derotation+procedure.">Vascular anatomy of mesopancreas in pancreatoduodenectomy using an intestinal derotation procedure.</a> World Journal of Surgery. 44 (10), 3441-3448 (2020).</li><li>Zhu, C. -. 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With intestinal rotation, the ventral pancreas flips to the dorsal side and unites with the dorsal pancreas throughout the development of the human embryo, and the ventral pancreas also grows into the lower portion of the pancreatic head and the uncinate process1. The pancreatic uncinate process is described as the protrusion from the bottom left of the pancreatic head that is situated behind the SMA and the SMV1. 
In the meantime, the mesopancre...

The pancreatic uncinate process is the protrusion from the bottom left of the pancreatic head that is situated behind the SMA and superior mesenteric vein (SMV)1. The management of the uncinate process is a challenging area in pancreatic surgery due to its deep anatomy and challenging exposure; therefore, especially for pancreatic cancer located in the uncinate process, surgery is prone to result in a positive surgical margin, incomplete lymph node dissection, and poor prognosis2. Therefore, improved surgical techniques and strategies are urgently required.
Most resection procedures of the pancreatic head and uncinate process are performed along the right side of the SMV and SMA3. Although this approach largely works for ampullary tumors, it has drawbacks for pancreatic head cancer, particularly for large tumors in the uncinate process2. During the procedure, it is frequently required to spin and pull the SMV and SMA in order to expose them. The IPDA cannot be dissected clearly with such approaches, which usually results in bleeding or insufficient cleaning of the area. In this work, the authors describe an approach that can support the early control of the IPDA, which results in better bleeding control, less blood loss, and better dissection of the uncinate process.
Meanwhile, conventional laparotomy or laparoscopy pancreatoduodenectomy requires a Kocher maneuver for the wide mobilization of the duodenum and pancreatic head4. However, with this maneuver, the tumor cells have the potential capacity to metastasize via the portal vein (PV), as the surgeon might squeeze the tumor while holding it during surgery4,5,6. The no-touch isolation technique is one of the popular concepts in pancreatoduodenectomy. Although it has not been proven by large clinical trials whether this surgical intervention could enhance the cancer-related prognosis of pancreatic cancer patients, the study of Hirota et al.7 reported the significance of no-touch technology in preventing cancer cell metastasis by using molecular markers (CEA mRNA) to detect cancer cells in the portal vein blood. In their study, the no-touch technique group had a lower spread rate of portal vein cancer cells and a higher 3 year survival rate than the conventional technique group. No-touch LPD has been reported by the team of the current authors previously as an ideal oncological operation process fitting the &#34;tumor-free&#34; principle8,9.
This article presents the management of the uncinate process in no-touch LPD. The median-anterior and left-posterior approaches to the SMA were performed to deal precisely with the IPDA. To achieve the no-touch isolation technique in LPD, the blood supply to the duodenum and pancreatic heads must be cut off at the very early stage of the operation, after which the tumor can be isolated intact, resected in situ, and finally, removed en bloc.
The purpose and advantages of this strategy are to ensure the safe and complete excision of the uncinate process and mesopancreas based on a multi-angle arterial approach10. This article aims to explore the efficacy and safety of this technique for the management of the uncinate process in no-touch LPD, which might improve the R0 resection rate11.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>3D Laparoscope</td>
			<td>STORZ</td>
			<td>TC200,TC302</td>
			<td></td>
		</tr>
		<tr>
			<td>Cisatracurium Besylate Injection</td>
			<td>Hengrui Pharma</td>
			<td>H20183042</td>
			<td></td>
		</tr>
		<tr>
			<td>Dual-source dual-energy&#160; CT</td>
			<td>SOMATOM</td>
			<td>Definition FLASH</td>
			<td></td>
		</tr>
		<tr>
			<td>Echelon Flex Powered Plus Articulating Endoscopic Linear Cutter and Endopath Echelon Endoscopic Linear Cutter Reloads with Gripping Surface Technology</td>
			<td>Ethicon Endo-Surgery</td>
			<td>ECR60G/GST60G</td>
			<td></td>
		</tr>
		<tr>
			<td>ENDOPATH XCEL Trocars</td>
			<td>Johnson &#38; Johnson</td>
			<td>CB5LT/CB12LT</td>
			<td></td>
		</tr>
		<tr>
			<td>HARMONIC ACE Ultrasonic Surgical Devices</td>
			<td>Ethicon Endo-Surgery</td>
			<td>HAR36</td>
			<td></td>
		</tr>
		<tr>
			<td>Laparoscopic bulldog clamps</td>
			<td>Aesculap</td>
			<td>FB367R,FB369R</td>
			<td></td>
		</tr>
		<tr>
			<td>Ligating Clips</td>
			<td>Teleflex Medical</td>
			<td>5,44,22,05,44,23,05,44,000</td>
			<td></td>
		</tr>
		<tr>
			<td>Nacrotrend anaesthesia monitoring system&#160;</td>
			<td>Monitor Technik,Bad Bramsted</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>PROLENE Polypropylene Nonabsorbable Suture/5/0</td>
			<td>Johnson &#38; Johnson</td>
			<td>W8556</td>
			<td></td>
		</tr>
		<tr>
			<td>Propofol Injectable Emulsion</td>
			<td>Aspen Pharma Trading Limited</td>
			<td>H20171275</td>
			<td></td>
		</tr>
		<tr>
			<td>Remifentanil Hydrochloride for injection</td>
			<td>Humanwell Healthcare</td>
			<td>H20030197</td>
			<td></td>
		</tr>
		<tr>
			<td>Sevoflurane for Inhalation</td>
			<td>Hengrui Pharma</td>
			<td>H20070172</td>
			<td></td>
		</tr>
		<tr>
			<td>Sufentanil Citrate Injecton</td>
			<td>Humanwell Healthcare</td>
			<td>H20054171</td>
			<td></td>
		</tr>
		<tr>
			<td>Trocars</td>
			<td>AOFO</td>
			<td>FQ-D1/5.5mm 10.5mm</td>
			<td></td>
		</tr>
		<tr>
			<td>Ultrasonic Surgical &#38; Electrosurgical Generator</td>
			<td>Ethicon Endo-Surgery</td>
			<td>GEN11CN</td>
			<td></td>
		</tr>
	</tbody>
</table>

management of the uncinate process in no-touch laparoscopic pancreaticoduodenectomy

Laparoscopic pancreatoduodenectomy (LPD) is a demanding abdominal operation that necessitates meticulous surgical skills and teamwork. The management of the pancreatic uncinate process is one of the most important and difficult processes in LPD because of its deep anatomical location and difficult exposure. Complete resection of the uncinate process and mesopancreas has become the cornerstone of LPD. In particular, it is even more difficult to avoid positive surgical margins and incomplete lymph node dissection when the tumor is located in the uncinate process. No-touch LPD, which is an ideal oncological operation process fitting the "tumor-free" principle, has been reported by our group previously. This article introduces the management of the uncinate process in no-touch LPD. Based on the multi-angle arterial approach, in this protocol, the median-anterior and left-posterior approaches to the SMA are used to correctly deal with the important vascular structure, the inferior pancreaticoduodenal artery (IPDA), in order to ensure the safe and complete excision of the uncinate process and mesopancreas. For the achievement of the no-touch isolation technique in LPD, the pancreatic head and the blood supply to the duodenal region must be severed at the very early stage of the operation; after that, the tumor can be isolated intact, resection can be performed in situ, and finally, the tissue can be removed en bloc. This paper aims to show the distinctive ways to manage the uncinate process in no-touch LPD and investigate the viability and safety of this approach. Moreover, the technique may increase the R0 resection rate.

A male patient aged 59 years old with symptoms including upper abdominal pain and jaundice was hospitalized in our department. He had no previous medical history and a relatively moderate normal body mass index (23.94 kg/m2). A contrast-enhanced CT scan was performed, and a tumor with a diameter of approximately 5.5 cm x 4.6 cm x 6.3 cm was found at the head and uncinate process of the pancreas (Figure 10). No evidence of distant metastasis was found, and percutaneous transhepatic cholangica...

Watch this Scientific Journal Video about Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy at JoVE.com

Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy

Complete resection of the uncinate process and mesopancreas is one of the most important and difficult processes in laparoscopic pancreatoduodenectomy (LPD). This article presents a method for managing the uncinate process in no-touch LPD using the median-anterior and left-posterior approaches to the superior mesenteric artery (SMA).

Laparoscopic pancreatoduodenectomy (LPD) is a demanding abdominal operation that necessitates meticulous surgical skills and teamwork. The management of ...

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