VA Boston

1 ARTICLES PUBLISHED IN JoVE

Behavior

Chronic Social Defeat Stress in Early Adolescent Male Mice

Miranda R. Mayeaux¹, Emily L. Newman², Kerry J. Ressler², Erin E. Hisey^1,2,3

¹VA Boston, ²McLean Hospital, ³Boston University Medical Center

This protocol details how to perform 10 day chronic social defeat stress in early adolescent male mice to produce long-lasting social avoidance in adulthood in more than 60% of mice.