Assessing the Effect of TMOD3 on Overall Survival and Progression-Free Survival (PFS) in Ovarian Cancer Patients

To begin, go to UALCAN and click on the proteomics menu. Insert TMOD3 in the enter gene names box. Choose ovarian cancer in the CPTAC dataset box, and click on explore to get the results.

Then, go to KM plotter and click on start KM plotter for ovarian cancer. Insert TMOD3 in the Affy id or gene symbol box. After that, choose auto select best cutoff in split patients by box.

When performing prognosis analysis for platinum-based chemotherapy patients, select the chemotherapy option that contains platin. Choose TCGA in use following datasets for the analysis box. At last, click on draw Kaplan-Meier plot to get the results.

Protein levels of TMOD3 were significantly higher in ovarian cancer than in normal ovarian tissues. TMOD3 expression levels decreased after cisplatin treatment in the ovarian cancer CH1 cell line, and were lower in ovarian cancer xenograft mice treated with carboplatin, compared to untreated ones. TMOD3 expression was significantly higher in cisplatin-resistant ovarian cancer cell line A2780, compared to the cisplatin-sensitive group, and higher in cisplatin-resistant ovarian cancer spheroid expression, compared to the cisplatin-sensitive group.