Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

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27.1K Views

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08:59 min

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February 25th, 2015

DOI :

10.3791/52309-v

February 25th, 2015

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Kevin Nelson¹^,², Christopher Bobba¹^,², Emre Eren³, Tyler Spata⁴, Malak Tadres², Don Hayes, Jr.⁵^,⁶, Sylvester M. Black³^,⁷, Samir Ghadiali*¹^,²^,³, Bryan A. Whitson*²^,³^,⁴

¹Department of Biomedical Engineering, Ohio State University Wexner Medical Center, ²Davis Heart & Lung Research Institute, Ohio State University Wexner Medical Center, ³The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, Ohio State University Wexner Medical Center, ⁴Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, ⁵Departments of Pediatrics and Internal Medicine, Ohio State University, ⁶Advanced Lung Disease Program, Lung and Heart-Lung Transplant Programs, Nationwide Children's Hospital, ⁷Division of Transplantation, Department of Surgery, Ohio State University Wexner Medical Center

Podsumowanie

Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess organs and expand the donor pool. Here, we describe the development of a rat EVLP program and refinements that allow for a reproducible model for future expansion.

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