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The selectivty and anti-metastatic activity of oral bioavailable butyric acid prodrugs.
Investigational new drugs Sep, 2006 | Pubmed ID: 16502348
Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex).
Clinical & experimental metastasis , 2008 | Pubmed ID: 18506586
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
Journal of medicinal chemistry May, 2009 | Pubmed ID: 19378992
The histone deacetylase inhibitor butyroyloxymethyl diethylphosphate (AN-7) protects normal cells against toxicity of anticancer agents while augmenting their anticancer activity.
Investigational new drugs Feb, 2012 | Pubmed ID: 20862515
Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor.
PloS one , 2012 | Pubmed ID: 22384017
A novel valproic acid prodrug as an anticancer agent that enhances doxorubicin anticancer activity and protects normal cells against its toxicity in vitro and in vivo.
Biochemical pharmacology Mar, 2014 | Pubmed ID: 24463168
The Therapeutic Potential of AN-7, a Novel Histone Deacetylase Inhibitor, for Treatment of Mycosis Fungoides/Sezary Syndrome Alone or with Doxorubicin.
PloS one , 2016 | Pubmed ID: 26752418
Bi-functional prodrugs of 5-aminolevulinic acid and butyric acid increase erythropoiesis in anemic mice in an erythropoietin-independent manner.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Aug, 2016 | Pubmed ID: 27283485
Effects of histone deacetylase inhibitory prodrugs on epigenetic changes and DNA damage response in tumor and heart of glioblastoma xenograft.
Investigational new drugs Aug, 2017 | Pubmed ID: 28315153
AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair.
Investigational new drugs Feb, 2018 | Pubmed ID: 28884410
Comparison of the anticancer properties of a novel valproic acid prodrug to leading histone deacetylase inhibitors.
Journal of cellular biochemistry Apr, 2018 | Pubmed ID: 29135083
The Histone Deacetylase Inhibitor AN7, Attenuates Choroidal Neovascularization in a Mouse Model.
International journal of molecular sciences Feb, 2019 | Pubmed ID: 30736437
Valproic Acid Prodrug Affects Selective Markers, Augments Doxorubicin Anticancer Activity and Attenuates Its Toxicity in a Murine Model of Aggressive Breast Cancer.
Pharmaceuticals (Basel, Switzerland) Nov, 2021 | Pubmed ID: 34959644
Palbociclib in combination with sunitinib exerts a synergistic anti-cancer effect in patient-derived xenograft models of various human cancers types.
Cancer letters Jun, 2022 | Pubmed ID: 35358627
Felsenstein Medical Research Center
Davidoff Center, Rabin Medical Center
Neta Moskovits1,2,
Ella Itzhaki1,2,
Nataly Tarasenko1,2,
Eva Chausky1,2,
Avital Bareket-Samish3,
Aleksandr Kaufman1,2,
Raisa Meerson1,2,
Salomon M. Stemmer1,2,4
1, Felsenstein Medical Research Center,
2, Davidoff Center, Rabin Medical Center,
3, BioInsight Ltd.,
4Sackler Faculty of Medicine, Tel Aviv University
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