Senior Project Leader
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Investigation of RNA-protein and RNA-metal ion interactions by electron paramagnetic resonance spectroscopy. The HIV TAR-Tat motif.
Chemistry & biology Jun, 2002 | Pubmed ID: 12079781
Electron paramagnetic resonance dynamic signatures of TAR RNA-small molecule complexes provide insight into RNA structure and recognition.
Biochemistry Dec, 2002 | Pubmed ID: 12475232
Nanometer distance measurements on RNA using PELDOR.
Journal of the American Chemical Society Mar, 2003 | Pubmed ID: 12643697
EPR spectroscopic analysis of TAR RNA-metal ion interactions.
Biochemical and biophysical research communications Apr, 2003 | Pubmed ID: 12659878
A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III.
The EMBO journal Jul, 2004 | Pubmed ID: 15192703
Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.
Chemistry & biology Mar, 2005 | Pubmed ID: 15797217
Monitoring tat peptide binding to TAR RNA by solid-state 31P-19F REDOR NMR.
Nucleic acids research , 2005 | Pubmed ID: 15961729
EPR spectroscopic analysis of U7 hammerhead ribozyme dynamics during metal ion induced folding.
Biochemistry Sep, 2005 | Pubmed ID: 16171402
Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition.
Structure (London, England : 1993) Sep, 2006 | Pubmed ID: 16962976
Riboswitches: small-molecule recognition by gene regulatory RNAs.
Current opinion in structural biology Jun, 2007 | Pubmed ID: 17574837
Site-specific incorporation of nitroxide spin-labels into 2'-positions of nucleic acids.
Nature protocols , 2007 | Pubmed ID: 17703207
Structural basis for specific, high-affinity tetracycline binding by an in vitro evolved aptamer and artificial riboswitch.
Chemistry & biology Oct, 2008 | Pubmed ID: 18940672
Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase.
Nature structural & molecular biology Mar, 2009 | Pubmed ID: 19234468
Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch.
RNA (New York, N.Y.) Jan, 2010 | Pubmed ID: 19948769
X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source.
Journal of structural and functional genomics Mar, 2010 | Pubmed ID: 20364333
Structure of a Burkholderia pseudomallei trimeric autotransporter adhesin head.
PloS one , 2010 | Pubmed ID: 20862217
Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional spectroscopic probe C.
Nucleic acids research May, 2011 | Pubmed ID: 21252294
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
Journal of structural and functional genomics Jul, 2011 | Pubmed ID: 21359640
SAD phasing using iodide ions in a high-throughput structural genomics environment.
Journal of structural and functional genomics Jul, 2011 | Pubmed ID: 21359836
Fragment screening of infectious disease targets in a structural genomics environment.
Methods in enzymology , 2011 | Pubmed ID: 21371605
Structural basis of the substrate specificity of bifunctional isocitrate dehydrogenase kinase/phosphatase.
Biochemistry Sep, 2011 | Pubmed ID: 21870819
Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis.
BMC structural biology , 2011 | Pubmed ID: 21995815
Nanovolume optimization of protein crystal growth using the microcapillary protein crystallization system.
Journal of applied crystallography Oct, 2010 | Pubmed ID: 22477778
Structure of hepatitis C virus polymerase in complex with primer-template RNA.
Journal of virology Jun, 2012 | Pubmed ID: 22496223
Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.
Protein science : a publication of the Protein Society Jul, 2012 | Pubmed ID: 22544630
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23139410
Combining functional and structural genomics to sample the essential Burkholderia structome.
PloS one , 2013 | Pubmed ID: 23382856
Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D.
Biochimie Jul, 2013 | Pubmed ID: 23523511
Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.
Journal of structural and functional genomics Jun, 2013 | Pubmed ID: 23709284
Brianna L. Armour*,1,
Steve R. Barnes*,2,
Spencer O. Moen2,
Eric Smith3,
Amy C. Raymond4,
James W. Fairman5,
Lance J. Stewart6,
Bart L. Staker7,
Darren W. Begley5,
Thomas E. Edwards8,
Donald D. Lorimer9
1Protein Crystallization Lab, Emerald Bio,
2Molecular Biology Lab, Emerald Bio,
3Scientific Sales Representative, Emerald Bio,
4Group Leader II, Emerald Bio,
5Group Leader I, Emerald Bio,
6Chair of Advisory Board, Emerald Bio,
7Director of Multi-Target Services, Emerald Bio,
8Senior Project Leader, Emerald Bio,
9Project Leader II & SSGCID Site Manager, Emerald Bio
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