Frederick National Laboratory for Cancer Research sponsored by National Cancer Institute

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate (LAL) Assays

Barry W. Neun¹, Marina A. Dobrovolskaia¹

¹Nanotechnology Characterization Lab., Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by National Cancer Institute

Detection of endotoxins in engineered nanomaterials represents one of the grand challenges in the field of nanomedicine. Here, we present a case study that describes the framework composed of three different LAL formats to estimate potential endotoxin contamination in nanoparticles.