Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell CarcinomaJan Hagemann *1, Christian Jacobi *2, Sabine Gstoettner 3, Christian Welz 4, Sabina Schwenk-Zieger 3, Roland Stauber 1, Sebastian Strieth 1, Julian Kuenzel 1, Philipp Baumeister 3, Sven Becker 1,3
1Department of Otorhinolaryngology, Johannes-Gutenberg University Medical Center, 2Department of Otorhinolaryngology, Technical University of Munich Medical Center, 3Department of Otorhinolaryngology, Ludwig-Maximilian-University Medical Center, 4Department of Otorhinolaryngology, University of Goettingen Medical Center
We describe the evolution of a spheroid-based, three-dimensional in vitro model that enables us to test the current standard of experimental therapy regimens for head and neck squamous cell carcinoma on cell lines, aiming at evaluating therapy susceptibility and resistance on primary cells from human specimens in the future.
