Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's DiseaseSherri L. Thiele 1, Ruth Warre 1, Joanne E. Nash 1
1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough
A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing >95% loss of striatal dopamine and 90.63±-4.02 % ipsiversive rotational bias towards the side of the lesion.
