Ethanol and Metronidazole Treatment and Liver Regeneration in Larval Zebrafish
2:42
Chemical Screens in EtOH/MTZ-treated Larval Zebrafish
4:10
Ethanol and Metronidazole Treatment, and Liver Regeneration in Adult Zebrafish
5:24
Adult Zebrafish Liver Fixation, Immunostaining, and Confocal Imaging
7:30
Results: Hepatocyte Regeneration in Ethanol-treated Zebrafish Liver
9:25
Conclusion
Transcrição
The overall goal of this protocol is to establish an Ethanol-induced Fibrotic Liver Model in Zebrafish and to perform chemical screens using this model. This method can help answer key questions in the liver regeneration field. Such as the molecul
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Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.