The overall goal of this procedure is to measure functional motor impairments in the experimental autoimmune encephalomyelitis or EAE, mouse model multiple sclerosis using kinematic gait analysis. The application of kinematic gait analysis to mous
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Kinematic gait analysis in the sagittal plane yields highly precise information about how movement is executed. We describe the application of these techniques to identify gait deficits for mice subjected to autoimmune-mediated demyelination. These methods may also be used to characterize gait deficits for other mouse models featuring impaired locomotion.