Tumor Harvesting for Banking Tissue, Reimplantation, and Experiment Characterization
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Results: Analysis of Melanoma Patient-Derived Xenograft Models
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Conclusion
TRANSCRIÇÃO
The PDX has revolutionized the cancer experimental pre-clinical studies. We can now mimic, in the laboratory, what is happening in the patients. And now we can work on how to overcome the resistance and how, on the longterm, we can increase surviv
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Patient-derived xenograft (PDX) models more robustly recapitulate melanoma molecular and biological features and are more predictive of therapy response compared to traditional plastic tissue culture-based assays. Here we describe our standard operating protocol for the establishment of new PDX models and the characterization/experimentation of existing PDX models.