Lilin Ye

Institute of Immunology, Third Military Medical University

Affiliated withThird Military Medical University

Research Area

Cancer ResearchImmunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2021
Publication title	2024
Publication title	2024

Other Publications

Article	Year
The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection. Nature immunology\| PubMed ID: 26214740	2015
Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection. Nature\| PubMed ID: 27501245	2016
ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy\| PubMed ID: 27559856	2016
mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. Journal of virology\| PubMed ID: 27974559	2017
Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model. Cellular & molecular immunology\| PubMed ID: 28287115	2018
Antigen-specific CD8 T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin. Nature communications\| PubMed ID: 28537251	2017
Mammalian target of rapamycin complex 1 signalling is essential for germinal centre reaction. Immunology\| PubMed ID: 28557002	2017
Oral administration of visceral adipose tissue antigens ameliorates metabolic disorders in mice and elevates visceral adipose tissue-resident CD4CD25Foxp3 regulatory T cells. Vaccine\| PubMed ID: 28736203	2017
The differential organogenesis and functionality of two liver-draining lymph nodes in mice. Journal of autoimmunity\| PubMed ID: 28886898	2017
The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells. Immunity\| PubMed ID: 28930662	2017
Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5 and CXCR5 CD8 T Cells during Chronic HIV Infection. Frontiers in immunology\| PubMed ID: 29312314	2017
Analyzing Mouse B Cell Responses Specific to LCMV Infection. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29388097	2018
Flow Cytometry Analysis of mTOR Signaling in Antigen-Specific B Cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29388102	2018
Patient-shared TCRβ-CDR3 clonotypes correlate with favorable prognosis in chronic hepatitis B. European journal of immunology\| PubMed ID: 29856484	2018
Differentiation and Function of Follicular CD8 T Cells During Human Immunodeficiency Virus Infection. Frontiers in immunology\| PubMed ID: 29872434	2018
The Kinase Complex mTOR Complex 2 Promotes the Follicular Migration and Functional Maturation of Differentiated Follicular Helper CD4 T Cells During Viral Infection. Frontiers in immunology\| PubMed ID: 29875775	2018
B7S1, a novel candidate for anti-tumor checkpoint blockade immunotherapy. Science China. Life sciences\| PubMed ID: 30069671	2018
Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells. Nature medicine\| PubMed ID: 30297899	2018
A Portrait of CXCR5 Follicular Cytotoxic CD8 T cells. Trends in immunology\| PubMed ID: 30377045	2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function. Nature communications\| PubMed ID: 30451838	2018
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis. Immunity\| PubMed ID: 30709740	2019
Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature\| PubMed ID: 30814730	2019
The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection. Frontiers in immunology\| PubMed ID: 30814995	2019
Molecular Basis of the Differentiation and Function of Virus Specific Follicular Helper CD4 T Cells. Frontiers in immunology\| PubMed ID: 30828337	2019
The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection. Cellular & molecular immunology\| PubMed ID: 30842630	2019
Ceria nanoparticles promoted the cytotoxic activity of CD8 T cells by activating NF-κB signaling. Biomaterials science\| PubMed ID: 30968875	2019
The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection. Frontiers in immunology\| PubMed ID: 30984183	2019
Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8 T Cells in Acute Viral Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 31175159	2019
Sclerostin domain-containing protein 1 is dispensable for the differentiation of follicular helper and follicular regulatory T cells during acute viral infection. American journal of translational research\| PubMed ID: 31312383	2019
ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice. Nature communications\| PubMed ID: 31455769	2019
DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8 T cells. Cellular & molecular immunology\| PubMed ID: 31541182	2021
Improving the immunogenicity and protective efficacy of a whole-killed malaria blood-stage vaccine by chloroquine. Parasite immunology\| PubMed ID: 31644820	2020
T cell immune response within B-cell follicles. Advances in immunology\| PubMed ID: 31699216	2019
Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor. Cellular & molecular immunology\| PubMed ID: 32313207	2020
CD49aCD49b NK cells induced by viral infection reflect an activated state of conventional NK cells. Science China. Life sciences\| PubMed ID: 32335843	2020
Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis. Frontiers in immunology\| PubMed ID: 32477338	2020
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19. Signal transduction and targeted therapy\| PubMed ID: 32879307	2020
The Epigenetic Regulator EZH2 Instructs CD4 T Cell Response to Acute Viral Infection via Coupling of Cell Expansion and Metabolic Fitness. Journal of virology\| PubMed ID: 32999031	2020
METTL3-dependent mA modification programs T follicular helper cell differentiation. Nature communications\| PubMed ID: 33637761	2021
The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity. Signal transduction and targeted therapy\| PubMed ID: 33686064	2021
The lncRNA Snhg1-Vps13D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling. Signal transduction and targeted therapy\| PubMed ID: 33758164	2021
The metabolic hormone leptin promotes the function of T cells and supports vaccine responses. Nature communications\| PubMed ID: 34031386	2021
Sensitivity of SARS-CoV-2 Variants to Neutralization by Convalescent Sera and a VH3-30 Monoclonal Antibody. Frontiers in immunology\| PubMed ID: 34630430	2021
A novel linear and broadly neutralizing peptide in the SARS-CoV-2 S2 protein for universal vaccine development. Cellular & molecular immunology\| PubMed ID: 34645942	2021
The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4 T cells by preventing ferroptosis. Nature immunology\| PubMed ID: 34949833	2022
Differential expression of inhibitory receptor NKG2A distinguishes disease-specific exhausted CD8 T cells. MedComm\| PubMed ID: 35281793	2022
Prompt Antiviral Action of Pulmonary CD8+ T Cells Is Mediated by Rapid IFN-γ Induction and Its Downstream ISGs in the Lung. Frontiers in immunology\| PubMed ID: 35296070	2022
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD. Signal transduction and targeted therapy\| PubMed ID: 35383141	2022
A novel strategy to investigate the factors regulating the Treg to Tfr transition during acute viral infection. Journal of immunological methods\| PubMed ID: 35398062	2022
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope. Cell host & microbe\| PubMed ID: 35436443	2022
CD4 T-cell epitope-based heterologous prime-boost vaccination potentiates anti-tumor immunity and PD-1/PD-L1 immunotherapy. Journal for immunotherapy of cancer\| PubMed ID: 35580929	2022
Nasal Spray of Neutralizing Monoclonal Antibody 35B5 Confers Potential Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Small-Scale Clinical Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 35666466	2023
Tumor-Specific CD4 T Cells Restrain Established Metastatic Melanoma by Developing Into Cytotoxic CD4 T Cells. Frontiers in immunology\| PubMed ID: 35784297	2022
The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells. Frontiers in cellular and infection microbiology\| PubMed ID: 35909969	2022
A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern. Journal of virology\| PubMed ID: 35916510	2022
EZH2 restricts DNA methylation and promotes T differentiation during acute viral infection. Frontiers in immunology\| PubMed ID: 36045674	2022
The primordial differentiation of tumor-specific memory CD8 T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes. Cell\| PubMed ID: 36208623	2022
The m1A modification of tRNAs: a translational accelerator of T-cell activation. Cellular & molecular immunology\| PubMed ID: 36336727	2022
Role of CXCR5 CD8 T cells in human immunodeficiency virus-1 infection. Frontiers in microbiology\| PubMed ID: 36452930	2022
The land-scape of immune response to monkeypox virus. EBioMedicine\| PubMed ID: 36584594	2023
Bound to be perfect: Lck and T cell co-receptors. Nature immunology\| PubMed ID: 36596893	2023
Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity. Immunity\| PubMed ID: 36693372	2023
Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease. Science advances\| PubMed ID: 36857453	2023
Tumor-specific memory CD8 T cells are strictly resident in draining lymph nodes during tumorigenesis. Cellular & molecular immunology\| PubMed ID: 36859455	2023
A novel mAb broadly neutralizes SARS-CoV-2 VOCs in vitro and in vivo, including the Omicron variants. Journal of medical virology\| PubMed ID: 36912367	2023
Identification and Comparison of the Sialic Acid-Binding Domain Characteristics of Avian Coronavirus Infectious Bronchitis Virus Spike Protein. Journal of virology\| PubMed ID: 37097156	2023
The G allele of SNP rs3922 reduces the binding affinity between IGF2BP3 and CXCR5 correlating with a lower antibody production. European journal of immunology\| PubMed ID: 37141498	2023
Author Correction: Tumor-specific memory CD8 T cells are strictly resident in draining lymph nodes during tumorigenesis. Cellular & molecular immunology\| PubMed ID: 37225839	2023
PD-1/PD-L1 blockade restores tumor-induced COVID-19 vaccine bluntness. Vaccine\| PubMed ID: 37400286	2023
An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant. One health advances\| PubMed ID: 37521533	2023
The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation. Cell discovery\| PubMed ID: 37528081	2023
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment. Cellular & molecular immunology\| PubMed ID: 37644165	2023
Dopamine Receptor 1 Impedes ILC2-Mediated Antitumor Immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 37728417	2023
The role of CD4 T cells in tumor and chronic viral immune responses. MedComm\| PubMed ID: 37829505	2023
Functional diversification and dynamics of CAR-T cells in patients with B-ALL. Cell reports\| PubMed ID: 37851569	2023
Role of tumor cell pyroptosis in anti-tumor immunotherapy. Cell insight\| PubMed ID: 38464416	2024
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8 T cell effector functions. Immunity\| PubMed ID: 38479384	2024
An oncolytic virus delivering tumor-irrelevant bystander T cell epitopes induces anti-tumor immunity and potentiates cancer immunotherapy. Nature cancer\| PubMed ID: 38609488	2024