Commitment is the process whereby stem cells:
The multipotent hematopoietic stem cells, (HSCs), differentiate into the multipotent hematopoietic progenitor cells, (HPCs). The HPCs express many lineage-specific cytokine receptors. Each of these receptors binds specific cytokines, activates distinct signaling pathways, and expresses a particular gene set. The HPCs further differentiate to form committed progenitors, forming either common myeloid progenitors (CMPs) or common lymphoid progenitors (CLPs). The CMPs and CLPs proliferate, self-renew, and further differentiate into mature blood cells and immune cells depending on the receptors they express and the specific cytokines that bind. For example:
Thus, lineage commitment helps HSCs lose their multipotency and differentiate into more restricted cell fate.
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved