JoVE Encyclopedia of Experiments
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Encyclopedia of Experiments
Effect of an Immunomodulatory Pharmacological Agent on the Interaction Between Dendritic Cells and CD4+ T Cells
Overview
This video demonstrates a method of converting dendritic cells (DCs) to tolerogenic DCs (TolDCs) using an immunomodulatory pharmacological agent. This conversion is confirmed by evaluating the TolDC function through their immunosuppressive effect on CD4+ T cells.
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Source: Wei, H., et al. Development and Functional Characterization of Murine Tolerogenic Dendritic Cells. J. Vis. Exp. (135), (2018).
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