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Abstract

Medicine

[18f] fdg 示踪剂在重型颅脑损伤患者中的半定量评价

Published: November 9th, 2018

DOI:

10.3791/58641

1Division of Neurosurgery, Rehabilitation Center for Traumatic Apallics Chiba, National Agency for Automotive Safety and Victims' Aid, 2Division of PET imaging, Rehabilitation Center for Traumatic Apallics Chiba, National Agency for Automotive Safety and Victims' Aid, 3Tokyo Nuclear Services Co. Ltd., 4Department of Neurological Surgery, Graduate School of Medicine, Chiba University

Abstract

严重创伤性脑损伤 (stbi) 患者很难知道他们是否准确地表达自己的想法和情绪, 因为意识障碍, 大脑功能紊乱, 和语言障碍。由于沟通能力不足, 需要对家庭成员、医务人员和照顾者进行客观评价。其中一个评估是对大脑功能区域的评估。近年来, 多模态脑成像被用来探索受损大脑区域的功能。[18f]-氟脱氧葡萄糖正电子发射断层扫描断层扫描 ([18f] fdg-pet/ct) 是检查大脑功能的成功工具。然而, 基于 [18f] fdg-pet变 ct 的脑葡萄糖代谢评估没有标准化, 取决于几个不同的参数, 以及患者的情况。在这里, 我们描述了一系列半定量的评估协议, 用于使用 stbi 患者中自行生成的 [18 f] fdg 跟踪器进行感兴趣区域 (roi) 图像分析。该协议的重点是筛选参与者, 准备 [18f] fdg 跟踪器在热实验室, 安排获取 [18f] fdg-pet变 ct 脑图像, 并使用来自目标大脑区域的 roi 分析测量葡萄糖代谢。

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