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In This Article

  • Summary
  • Abstract
  • Introduction
  • Protocol
  • Representative Results
  • Discussion
  • Acknowledgements
  • Materials
  • References
  • Reprints and Permissions

Summary

Here, based on a clinician’s point-of-view, we propose a two-model lower body positive pressure (LBPP) protocol (walking and squatting models) in addition to a clinical, functional assessment methodology, including details for further encouragement of the development of non-drug surgical intervention strategies in knee osteoarthritis patients. However, we only present the effect of LBPP training in improvement of pain and knee function in one patient through three-dimensional gait analysis. The exact, long-term effects of this approach should be explored in future studies.

Abstract

Here, based on a clinician’s point-of-view, we propose a two-model lower body positive pressure (LBPP) protocol (walking and squatting models) in addition to a clinical, functional assessment methodology, including details for further encouragement of the development of non-drug surgical intervention strategies in knee osteoarthritis patients. However, we only present the effect of LBPP training in improvement of pain and knee function in one patient through three-dimensional gait analysis. The exact, long-term effects of this approach should be explored in future studies.

Introduction

Knee osteoarthritis (OA) is a progressive degenerative joint condition and a major cause of pain and locomotor disability in people all over the world1. Knee OA is characterized by osteophyte and cyst formation, narrow joint spacing, and subchondral bone sclerosis2. These pathological changes make it difficult to perform essential activities of daily living such as walking, squatting, and going up and down stairs3. However, physical activity is recommended as an essential component of first-line knee OA management4. Exercise intervention for knee OA rehabilitation is affect....

Protocol

The clinical project was approved by the Medical Ethics Association of the Fifth Affiliated Hospital of Guangzhou Medical University and has been registered at the China Clinical Trial Registration Center (No. ChiCTR1800017677 and entitled “Effect and Mechanism of Anti-gravity Treadmill on Lower Limb Motor Function in Patients with Knee Osteoarthritis”).

1. Recruitment

  1. Recruit patients presenting with radiographic evidence of mild-to-moderate (Kellgren & Lawrence gr.......

Representative Results

We show results from a knee OA patient, who was a 60-year-old female (BMI = 22.9) undergoing “more than 3 years of knee osteoarthritis” and severe pain when she was walking (visual analog scale [VAS] = 8/10) and participated in a 2-week LBPP training program at our facility. During the entire intervention, the patient did not take any painkillers to relieve knee pain. The radiological image of her knee joints and the results of clinical function assessments are shown in Figure 3 .......

Discussion

We proposed an LBPP treadmill intervention protocol, which includes both clinical assessment and treatment models, for the rehabilitation of lower extremity motor function in knee OA. Meanwhile, in response to the clinical symptoms and knee OA dysfunction, the treatment model includes not only a training section for walking in the LBPP protocol but also an innovative squatting training section, which aims to solve the daily dysfunction due to thigh muscle weakness and squatting difficulties in knee OA patients. To the be.......

Acknowledgements

This study was funded by Guangzhou Medical University (Grant Number 2018A053).

....

Materials

NameCompanyCatalog NumberComments
AlterG Anti-Gravity Treadmill M320AlterG Inc, Fremont, CA, USA1LBBP training
BTS Smart DX systemBioengineering Technology System, Milan, Italy2Temporospatial data collection
BTS FREEEMGBioengineering Technology System, Milan, Italy3Surface EMG data collection
BTS SMART-Clinic softwareBioengineering Technology System, Milan, Italy4Data processing

References

  1. McAlindon, T. E., et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 22, 363-388 (2014).
  2. Luyten, F. P., Denti, M., Filardo, G., Kon, E., Engebretsen, L. Definit....

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