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Abstract
Cancer Research
磁共振引导的高强度聚焦超声产生热疗：小鼠横纹肌肉瘤模型中的可行治疗方法
ERRATUM NOTICE
Important: There has been an erratum issued for this article. Read more …Abstract
磁共振引导的高强度聚焦超声（MRgHIFU）是一种产生局部热疗的既定方法。考虑到实时成像和声能调制，这种模式可以在定义的区域内实现精确的温度控制。这种非侵入性、非电离技术正在探索许多热应用，例如热疗产生，以从热敏脂质体载体中释放药物。这些药物可以包括化疗，如阿霉素，由于剂量限制性全身副作用，即心脏毒性，需要靶向释放。多柔比星是治疗多种恶性肿瘤的主要药物，通常用于复发或复发性横纹肌肉瘤 （RMS）。RMS是儿童和年轻人中最常见的实体性软组织颅外肿瘤。尽管进行了积极的多模式治疗，但RMS存活率在过去30年中保持不变。为了探索解决这一未满足需求的解决方案，开发了一种实验方案，以评估使用MRgHIFU作为药物释放热疗源的免疫功能正常的同系RMS小鼠模型中热敏脂质体阿霉素（TLD）的释放。
Erratum
Erratum: Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma ModelAn erratum was issued for: Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model . The Authors section was updated from:
Claire Wunker1,2
Karolina Piorkowska3
Ben Keunen3
Yael Babichev2
Suzanne M. Wong3,4
Maximilian Regenold5
Michael Dunne5
Julia Nomikos1,2
Maryam Siddiqui6
Samuel Pichardo6
Warren Foltz7
Adam C. Waspe3,8
Justin T. Gerstle3,9
Rebecca A. Gladdy1,2,10
1 Institute of Medical Science, University of Toronto
2 2Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
3 The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children
4 Institute of Biomedical Engineering, University of Toronto
5 Leslie Dan Faculty of Pharmacy, University of Toronto
6 Departments of Radiology and Clinical Neurosciences, University of Calgary
7 Department of Radiation Oncology, University of Toronto
8 Department of Medical Imaging, University of Toronto
9 Department of Pediatric Surgery, University of Toronto
10 Department of Surgery, University of Toronto
to:
Claire Wunker1,2
Karolina Piorkowska3
Ben Keunen3
Yael Babichev2
Suzanne M. Wong3,4
Maximilian Regenold5
Michael Dunne5
Julia Nomikos1,2
Maryam Siddiqui6
Samuel Pichardo6
Warren Foltz7
Adam C. Waspe3,8
Justin T. Gerstle3,9
James M. Drake1,3,4,10
Rebecca A. Gladdy1,2,10
1 Institute of Medical Science, University of Toronto
2 Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
3 The Wilfred and Joyce Posluns Centre for Image-Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children
4 Institute of Biomedical Engineering, University of Toronto
5 Leslie Dan Faculty of Pharmacy, University of Toronto
6 Departments of Radiology and Clinical Neurosciences, University of Calgary
7 Department of Radiation Oncology, University of Toronto
8 Department of Medical Imaging, University of Toronto
9 Department of Pediatric Surgery, University of Toronto
10 Department of Surgery, University of Toronto
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