Elena Aikawa

Cardiovascular Division, Brigham and Women's Hospital

Affiliated withBrigham and Women's Hospital Harvard Medical School Brigham and Women’s Hospital, Harvard Medical School

Research Area

MedicineBiology

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 28	2016
Publication title	2024

Other Publications

Article	Year
Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation\| PubMed ID: 16043658	2005
Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation\| PubMed ID: 16203910	2005
Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation\| PubMed ID: 16230484	2005
Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation\| PubMed ID: 16534030	2006
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy. Journal of biomedical optics\| PubMed ID: 16674184	2006
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation\| PubMed ID: 16682613	2006
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation\| PubMed ID: 16801460	2006
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16801531	2006
Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Molecular imaging\| PubMed ID: 16954022	2006
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-beta2. Circulation research\| PubMed ID: 16973908	2006
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation\| PubMed ID: 17000904	2006
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. The Journal of clinical investigation\| PubMed ID: 17200719	2007
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation\| PubMed ID: 17224478	2007
Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation\| PubMed ID: 17339546	2007
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circulation research\| PubMed ID: 17379832	2007
Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation\| PubMed ID: 17420353	2007
Healing and remodeling of bioengineered pulmonary artery patches implanted in sheep. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 17868878	2007
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. The Journal of experimental medicine\| PubMed ID: 18025128	2007
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation\| PubMed ID: 18040026	2007
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation\| PubMed ID: 18158358	2008
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain : a journal of neurology\| PubMed ID: 18234693	2008
Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusi... Circulation\| PubMed ID: 18268141	2008
Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. European heart journal\| PubMed ID: 18276618	2008
Simplified syntheses of complex multifunctional nanomaterials. Chemical communications (Cambridge, England)\| PubMed ID: 18830495	2008
Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis. Circulation\| PubMed ID: 18852366	2008
Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19011099	2008
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19015534	2008
Genetically engineered resistance for MMP collagenases promotes abdominal aortic aneurysm formation in mice infused with angiotensin II. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 19153555	2009
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. NeuroImage\| PubMed ID: 19154791	2009
Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation\| PubMed ID: 19307473	2009
Molecular imaging of innate immune cell function in transplant rejection. Circulation\| PubMed ID: 19332470	2009
The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular cancer therapeutics\| PubMed ID: 19509266	2009
Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. Circulation\| PubMed ID: 19597052	2009
Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19608968	2009
Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19644051	2009
Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science (New York, N.Y.)\| PubMed ID: 19644120	2009
Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves. Tissue engineering. Part A\| PubMed ID: 19698056	2010
Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study. Tissue engineering. Part C, Methods\| PubMed ID: 19751103	2010
Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circulation. Cardiovascular imaging\| PubMed ID: 19808594	2009
Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation. Journal of the American Chemical Society\| PubMed ID: 19817443	2009
18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC. Cardiovascular imaging\| PubMed ID: 19833312	2009
Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemi... Circulation. Cardiovascular imaging\| PubMed ID: 19920044	2009
Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circulation. Cardiovascular imaging\| PubMed ID: 19920045	2009
Notch signaling in cardiovascular disease and calcification. Current cardiology reviews\| PubMed ID: 19936191	2008
The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. Biomaterials\| PubMed ID: 19944458	2010
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20023731	2009
In vivo monitoring of function of autologous engineered pulmonary valve. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 20176213	2010
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. Journal of the American College of Cardiology\| PubMed ID: 20378083	2010
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation. European heart journal\| PubMed ID: 20601388	2010
Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20689078	2010
Mitral valve endothelial cells with osteogenic differentiation potential. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21164078	2011
Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata. European heart journal\| PubMed ID: 21292680	2011
Cardiovascular calcification: an inflammatory disease. Circulation journal : official journal of the Japanese Circulation Society\| PubMed ID: 21566338	2011
Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques. Science translational medicine\| PubMed ID: 21613624	2011
Molecular imaging insights into early inflammatory stages of arterial and aortic valve calcification. Circulation research\| PubMed ID: 21617135	2011
Progenitor cells confer plasticity to cardiac valve endothelium. Journal of cardiovascular translational research\| PubMed ID: 21789724	2011
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nature medicine\| PubMed ID: 21857652	2011
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21903941	2011
Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executi... Circulation\| PubMed ID: 22007101	2011
The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology\| PubMed ID: 22009730	2011
Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase. Radiology\| PubMed ID: 22084204	2012
Look more closely at the valve: imaging calcific aortic valve disease. Circulation\| PubMed ID: 22090164	2012
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123981	2011
Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22223731	2012
Cardiovascular inflammation. International journal of inflammation\| PubMed ID: 22518345	2012
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22699504	2012
Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. European heart journal\| PubMed ID: 22927557	2013
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS biology\| PubMed ID: 23271954	2012
Visualizing novel concepts of cardiovascular calcification. Trends in cardiovascular medicine\| PubMed ID: 23290463	2013
MicroRNA in cardiovascular calcification: focus on targets and extracellular vesicle delivery mechanisms. Circulation research\| PubMed ID: 23538277	2013
Cardiovascular Inflammation 2012: Reactive Oxygen Species, SUMOylation, and Biomarkers in Cardiovascular Inflammation. International journal of inflammation\| PubMed ID: 23555068	2013
Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques. Circulation research\| PubMed ID: 23616621	2013
Elastogenesis at the onset of human cardiac valve development. Development (Cambridge, England)\| PubMed ID: 23637335	2013
Leukocyte-derived microparticles as proinflammatory mediators in atherosclerosis. Journal of the American College of Cardiology\| PubMed ID: 23707315	2013
Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23733926	2013
Role of extracellular vesicles in de novo mineralization: an additional novel mechanism of cardiovascular calcification. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23766262	2013
Medial and intimal calcification in chronic kidney disease: stressing the contributions. Journal of the American Heart Association\| PubMed ID: 24060959	2013
Cystathionine γ-lyase accelerates osteoclast differentiation: identification of a novel regulator of osteoclastogenesis by proteomic analysis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24357058	2014
Potential drug targets for calcific aortic valve disease. Nature reviews. Cardiology\| PubMed ID: 24445487	2014
A novel quantitative approach for eliminating sample-to-sample variation using a hue saturation value analysis program. PloS one\| PubMed ID: 24595280	2014
Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation. Circulation research\| PubMed ID: 24677232	2014
Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24951650	2014
Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform. Advanced healthcare materials\| PubMed ID: 24958085	2015
Small entities with large impact: microcalcifications and atherosclerotic plaque vulnerability. Current opinion in lipidology\| PubMed ID: 25188916	2014
Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25189570	2014
EVpedia: a community web portal for extracellular vesicles research. Bioinformatics (Oxford, England)\| PubMed ID: 25388151	2015
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. Journal of extracellular vesicles\| PubMed ID: 25491249	2014
Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease. The American journal of pathology\| PubMed ID: 25680278	2015
Cardiovascular calcification: current controversies and novel concepts. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology\| PubMed ID: 25797772	2015
International Society for Extracellular Vesicles: Second Annual Meeting, 17-20 April 2013, Boston, MA (ISEV 2013). Journal of extracellular vesicles\| PubMed ID: 26082318	2013
A Not-So-Little Role for Lipoprotein(a) in the Development of Calcific Aortic Valve Disease. Circulation\| PubMed ID: 26224809	2015
Valvular interstitial cells suppress calcification of valvular endothelial cells. Atherosclerosis\| PubMed ID: 26232165	2015
Revisiting cardiovascular calcification: A multifaceted disease requiring a multidisciplinary approach. Seminars in cell & developmental biology\| PubMed ID: 26358815	2015
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PloS one\| PubMed ID: 26367531	2015
Mitral valve disease--morphology and mechanisms. Nature reviews. Cardiology\| PubMed ID: 26483167	2015
Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques. Nature materials\| PubMed ID: 26752654	2016
Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve. Journal of the American College of Cardiology\| PubMed ID: 26796392	2016
Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26800565	2016
Extracellular vesicles in cardiovascular calcification: Expanding current paradigms. The Journal of physiology\| PubMed ID: 26824781	2016
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. The Journal of clinical investigation\| PubMed ID: 26950419	2016
3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR. European heart journal cardiovascular Imaging\| PubMed ID: 26976355	2016
Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation. Journal of molecular and cellular cardiology\| PubMed ID: 26996755	2016
Zooming in on the genesis of atherosclerotic plaque microcalcifications. The Journal of physiology\| PubMed ID: 27040360	2016
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress. Circulation research\| PubMed ID: 28607103	2017
Macrophage Heterogeneity Complicates Reversal of Calcification in Cardiovascular Tissues. Circulation research\| PubMed ID: 28642321	2017
Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29191923	2018
Dimerization of sortilin regulates its trafficking to extracellular vesicles. The Journal of biological chemistry\| PubMed ID: 29382723	2018
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International journal of molecular sciences\| PubMed ID: 29495441	2018
Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel, Switzerland)\| PubMed ID: 29751516	2018
Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Scientific reports\| PubMed ID: 29899496	2018
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery. Nature reviews. Cardiology\| PubMed ID: 30531869	2019
Complex association of lipoprotein(a) with aortic stenosis. Heart (British Cardiac Society)\| PubMed ID: 32086294	2020
Innate and adaptive immunity in cardiovascular calcification. Atherosclerosis\| PubMed ID: 32222287	2020
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Science advances\| PubMed ID: 32938681	2020
ApoC-III is a novel inducer of calcification in human aortic valves. The Journal of biological chemistry\| PubMed ID: 33334888	2021
Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33795519	2021
Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imagi... Journal of the American Heart Association\| PubMed ID: 34632804	2021
Controlled delivery of gold nanoparticle-coupled miRNA therapeutics an injectable self-healing hydrogel. Nanoscale\| PubMed ID: 34817483	2021
Wnt Site Signaling Inhibitor Secreted Frizzled-Related Protein 3 Protects Mitral Valve Endothelium From Myocardial Infarction-Induced Endothelial-to-Mesenchymal Transition. Journal of the American Heart Association\| PubMed ID: 35348006	2022
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling. Cell reports\| PubMed ID: 35417712	2022
Elevated lipoprotein(a) as a predictor for coronary events in older men. Journal of lipid research\| PubMed ID: 35724702	2022