Edward J. Kelly

Department of Pharmaceutics, University of Washington

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2025

Other Publications

Article	Year
A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9294160	1997
Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9724794	1998
Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 11752683	2002
An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number. Genetic testing\| PubMed ID: 15727256	2004
The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice. Journal of pharmaceutical sciences\| PubMed ID: 15858856	2005
Characterization of the human MDR1 gene. The AAPS journal\| PubMed ID: 16146331	2005
Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 19661213	2009
Pharmacokinetics of metformin during pregnancy. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 20118196	2010
Pharmacogenetics of intravenous and oral busulfan in hematopoietic cell transplant recipients. Journal of clinical pharmacology\| PubMed ID: 21135089	2011
Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers. Transgenic research\| PubMed ID: 21538071	2012
Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states. Molecular interventions\| PubMed ID: 21540472	2011
Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Annals of hepatology\| PubMed ID: 21677335	2011
Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016. Journal of veterinary pharmacology and therapeutics\| PubMed ID: 21919916	2012
Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences. Biochemical and biophysical research communications\| PubMed ID: 22402285	2012
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. Molecular pharmacology\| PubMed ID: 22772592	2012
Hepatic Cyp2d and Cyp26a1 mRNAs and Activities are Increased During Mouse Pregnancy. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 23150428	2012
Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 23748241	2013
Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 24101703	2013
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem cell research & therapy\| PubMed ID: 24564863	2013
Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition. Drug metabolism reviews\| PubMed ID: 24856391	2014
Generation and characterization of a murine model of Bietti crystalline dystrophy. Investigative ophthalmology & visual science\| PubMed ID: 25118264	2014
Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. The Biochemical journal\| PubMed ID: 25247810	2015
Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochemical pharmacology\| PubMed ID: 25450675	2014
A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. Journal of the American Society of Nephrology : JASN\| PubMed ID: 26260164	2016
Pharmacokinetics of metoprolol during pregnancy and lactation. Journal of clinical pharmacology\| PubMed ID: 26461463	2016
CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 26965986	2016
Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. Clinical pharmacology and therapeutics\| PubMed ID: 27448090	2016
Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27468999	2016
Development of a microphysiological model of human kidney proximal tubule function. Kidney international\| PubMed ID: 27521113	2016
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27543206	2016
Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 27621205	2016
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 28089783	2017
Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in . The British journal of ophthalmology\| PubMed ID: 28698241	2018
Microphysiological Systems to Assess Nonclinical Toxicity. Current protocols in toxicology\| PubMed ID: 28777442	2017
Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Current opinion in toxicology\| PubMed ID: 29057384	2017
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 29138286	2018
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. JCI insight\| PubMed ID: 29202460	2017
Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system. ALTEX\| PubMed ID: 29999169	2018
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 30076203	2018
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Scientific reports\| PubMed ID: 30291268	2018
A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. Journal of the American Society of Nephrology : JASN\| PubMed ID: 30361326	2018
Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. Advanced healthcare materials\| PubMed ID: 30379416	2018
Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI insight\| PubMed ID: 30568031	2018
Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System. CPT: pharmacometrics & systems pharmacology\| PubMed ID: 30869201	2019
Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. The AAPS journal\| PubMed ID: 30919109	2019
A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS (London, England)\| PubMed ID: 31306173	2019
Tissue Chips in Space-Challenges and Opportunities. Clinical and translational science\| PubMed ID: 31524321	2020
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 31857146	2020
Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism. PloS one\| PubMed ID: 32101552	2020
Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology\| PubMed ID: 32905824	2020
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human. Molecular pharmaceutics\| PubMed ID: 32955894	2020
A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 33020068	2020
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Scientific reports\| PubMed ID: 33633318	2021
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: -oxidation as a potential... Xenobiotica; the fate of foreign compounds in biological systems\| PubMed ID: 33993844	2021
Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease. Scientific reports\| PubMed ID: 34002000	2021
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences. Clinical and translational science\| PubMed ID: 34378335	2022
Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing. Frontiers in pharmacology\| PubMed ID: 34381363	2021
Gutsy science: In vitro systems of the human intestine to model oral drug disposition. Pharmacology & therapeutics\| PubMed ID: 34478775	2022
Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Scientific reports\| PubMed ID: 34725352	2021
Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 35197326	2022
Kidney microphysiological models for nephrotoxicity assessment. Current opinion in toxicology\| PubMed ID: 35495549	2022
Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier. Molecular pharmacology\| PubMed ID: 37652713	2023
Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease. Pharmaceutical research\| PubMed ID: 37704895	2023
Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 37949747	2024
Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells. Pharmaceutics\| PubMed ID: 38399338	2024
Development of a kidney microphysiological system hardware platform for microgravity studies. NPJ microgravity\| PubMed ID: 38734683	2024
Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system. NPJ microgravity\| PubMed ID: 38982119	2024
Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 39884814	2025