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In Vitro Assessment of Cytotoxicity Mediated by Hypoxia-Sensitive CAR-T Cells

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01:57 min

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June 14th, 2024

DOI :

10.3791/201982-v

June 14th, 2024

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Ying Xue*¹, Yunyu Mao*², Qibin Liao³, Chen Zhao⁴, Xiaoyan Zhang¹^,²^,⁴, Jianqing Xu¹^,²^,⁴

¹Institutes of Biomedical Sciences, Fudan University, ²Clinical Center of Biotherapy at Zhongshan Hospital, Fudan University, ³Department of Oncology and Bio-therapeutic Center, Shenzhen Third People's Hospital, Southern University of Science and Technology, ⁴Shanghai Public Health Clinical Center, Fudan University

* These authors contributed equally

Transkript

Daha Fazla Video Keşfet

In Vitro Assessment

Hypoxia Sensitive CAR T Cells

Chimeric Antigen Receptor

Cytokine Detection

Passive Lysis Buffer

Luciferase Activity

HER2 Targeting CAR

Hypoxic Conditions

Normoxic Conditions

Seriden

Functional Validation of Hypoxia-Sensitive CAR-T Cells for Selective Tumors

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